Aspergillus lung disease in patients with sarcoidosis: a case series and review of the literature

Tahuanty A Pena; Ayman O Soubani; Lobelia Samavati

doi:10.1007/s00408-011-9280-9

Aspergillus lung disease in patients with sarcoidosis: a case series and review of the literature

Lung. 2011 Apr;189(2):167-72. doi: 10.1007/s00408-011-9280-9. Epub 2011 Feb 13.

Authors

Tahuanty A Pena¹, Ayman O Soubani, Lobelia Samavati

Affiliation

¹ Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Wayne State University School of Medicine, 3990 John R, 3 Hudson, Detroit, MI 48201, USA.

PMID: 21327836
DOI: 10.1007/s00408-011-9280-9

Abstract

Chronic cavitary pulmonary aspergillosis (CCPA) has been associated with advanced lung diseases. Pulmonary sarcoidosis, a granulomatous inflammatory disorder, is associated with CCPA. We identified CCPA in 2% of cases in a large cohort of sarcoidosis patients. We found a lack of response to medical treatment and poor outcome in this subgroup.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Aged
Antifungal Agents / therapeutic use
Female
Humans
Itraconazole / therapeutic use
Male
Middle Aged
Pulmonary Aspergillosis / drug therapy
Pulmonary Aspergillosis / epidemiology*
Pyrimidines / therapeutic use
Risk Factors
Sarcoidosis, Pulmonary / complications*
Treatment Outcome
Triazoles / therapeutic use
Voriconazole

Substances

Antifungal Agents
Pyrimidines
Triazoles
Itraconazole
Voriconazole