Role of titin in skeletal muscle function and disease

Adv Exp Med Biol. 2010:682:105-22. doi: 10.1007/978-1-4419-6366-6_6.

Abstract

This review covers recent developments in the titin field. Most recent reviews have discussed titin's role in cardiac function: here we will mainly focus on skeletal muscle, and discuss recent advances in the understanding of titin's role in skeletal muscle function and disease.

MeSH terms

  • Biomechanical Phenomena / physiology
  • Carrier Proteins / physiology
  • Connectin
  • Elasticity
  • Humans
  • Muscle Proteins / physiology*
  • Muscle, Skeletal / physiology*
  • Muscular Diseases / physiopathology*
  • Protein Isoforms / physiology
  • Protein Kinases / physiology*
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Sarcomeres / physiology

Substances

  • Carrier Proteins
  • Connectin
  • Muscle Proteins
  • Protein Isoforms
  • TTN protein, human
  • Protein Kinases