Abstract
Following primary and booster vaccination with an 11-valent pneumococcall protein D conjugate vaccine there was a 42.8% (95% CI: -16.7 to 71.9, ns) reduction in the carriage of Streptococcus pneumoniae vaccine serotypes and a 42.6% (95% CI: 1.3-66.6) reduction in the carriage of Haemophilus influenzae identified by standard microbiological techniques. When PCR and immunoblot assays were used to further improve specificity of non-typeable H. influenzae strain identification, carriage of H. influenzae was still reduced with 38.6% (95% CI: -6.3 to 64.6, ns). Reduction of acute otitis media (AOM) episodes preceded the impact on carriage. These data provide further support of the functional role of the protein D immunity.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / immunology
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Carrier Proteins / immunology
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Carrier State / immunology
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Carrier State / prevention & control*
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Child, Preschool
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DNA, Bacterial / isolation & purification
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Double-Blind Method
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Female
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Haemophilus Infections / immunology
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Haemophilus Infections / prevention & control*
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Humans
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Immunoglobulin D / immunology
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Infant
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Lipoproteins / immunology
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Male
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Nasopharynx / microbiology*
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Otitis Media / microbiology
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Otitis Media / prevention & control
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Pneumococcal Infections / immunology
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Pneumococcal Infections / prevention & control*
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Pneumococcal Vaccines / immunology*
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Polysaccharides, Bacterial / immunology*
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Prospective Studies
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Vaccines, Conjugate / immunology
Substances
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Bacterial Proteins
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Carrier Proteins
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DNA, Bacterial
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Immunoglobulin D
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Lipoproteins
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Pneumococcal Vaccines
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Polysaccharides, Bacterial
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Vaccines, Conjugate
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glpQ protein, Haemophilus influenzae