Prolonged fever, hepatosplenomegaly, and pancytopenia in a 46-year-old woman

PLoS Med. 2009 Apr 14;6(4):e1000053. doi: 10.1371/journal.pmed.1000053. Epub 2009 Apr 14.

Abstract

Liran Levy and colleagues discuss the differential diagnosis, investigation, and management of a 46-year-old woman with fever, weakness, night sweats, and weight loss.

Publication types

  • Case Reports
  • Clinical Conference

MeSH terms

  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / therapeutic use
  • Amphotericin B / therapeutic use
  • Animals
  • Communicable Diseases / diagnosis
  • Cyclosporine / adverse effects
  • Cyclosporine / therapeutic use
  • Diagnosis, Differential
  • Female
  • Fever / etiology*
  • Hepatomegaly / etiology*
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use
  • Leishmania infantum / immunology
  • Leishmania infantum / isolation & purification*
  • Leishmaniasis, Visceral / complications*
  • Leishmaniasis, Visceral / diagnosis
  • Leishmaniasis, Visceral / drug therapy
  • Liposomes
  • Lymphohistiocytosis, Hemophagocytic / complications
  • Lymphohistiocytosis, Hemophagocytic / diagnosis*
  • Lymphohistiocytosis, Hemophagocytic / drug therapy
  • Macrophages / parasitology
  • Middle Aged
  • Neoplasms / diagnosis
  • Opportunistic Infections / complications
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / immunology
  • Opportunistic Infections / parasitology
  • Pancytopenia / etiology*
  • Polymerase Chain Reaction
  • Splenomegaly / etiology*

Substances

  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Liposomes
  • liposomal amphotericin B
  • Amphotericin B
  • Cyclosporine