Abstract
IL-17 is produced not only by CD4(+) alphabeta T cells, but also CD8(+) alphabeta T cells, NKT cells, and gammadelta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, gammadelta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Autoimmune Diseases / immunology
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Autoimmune Diseases / metabolism
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Bacteria / immunology
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Bacterial Infections / immunology*
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Bacterial Infections / microbiology
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Cytokines / immunology
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Cytokines / metabolism
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Disease Models, Animal
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Humans
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Hypersensitivity / immunology
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Hypersensitivity / metabolism
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Inflammation / immunology
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Inflammation / metabolism
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Interleukin-17 / immunology*
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Interleukin-17 / metabolism
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Mice
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Receptors, Antigen, T-Cell, alpha-beta / immunology*
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Receptors, Antigen, T-Cell, alpha-beta / metabolism
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Receptors, Antigen, T-Cell, gamma-delta / immunology*
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Receptors, Antigen, T-Cell, gamma-delta / metabolism
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T-Lymphocyte Subsets / immunology*
Substances
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Cytokines
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Interleukin-17
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta