Hypertension, fetal growth restriction and obstructive sleep apnoea in pregnancy

Eur J Obstet Gynecol Reprod Biol. 2008 Nov;141(1):35-8. doi: 10.1016/j.ejogrb.2008.07.009. Epub 2008 Aug 30.

Abstract

Objective: To test the hypothesis that obstructive sleep apnoea (OSA) is more common in pregnancies complicated by hypertensive disease and fetal growth restriction.

Study design: An observational study comparing pregnant women with these two complications with normal pregnant women and non-pregnant women in two UK maternity hospitals. Each participant completed a sleep apnoea questionnaire and underwent nocturnal oxygen saturation monitoring.

Results: Using a strict definition of obstructive sleep apnoea confirmed by oxygen saturation monitoring only two mild cases were seen, 0/50 non-pregnant women, 1/69 of normal pregnant women, 0/48 women with various types of hypertensive disease, and 1/33 women carrying fetuses affected with fetal growth restriction. Even using less strict definitions and self-reported sleepiness scores there was no relation between sleep apnoea and either fetal growth restriction or hypertensive diseases.

Conclusion: Obstructive sleep apnoea is at most a rare cause of either growth restriction or hypertensive disease in pregnancy.

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • Fetal Growth Retardation / etiology*
  • Humans
  • Pre-Eclampsia*
  • Pregnancy
  • Sleep Apnea, Obstructive / complications*
  • Young Adult