TB or not TB: calcium regulation in mycobacterial survival

Cell. 2007 Jul 13;130(1):12-4. doi: 10.1016/j.cell.2007.06.039.

Abstract

Mycobacterium tuberculosis (Mtb)-the bacterium that causes tuberculosis-resides in phagosomes inside macrophages. This bacterium evades destruction by preventing phagosome maturation, which involves the fusion of phagosomes with lysosomes. In this issue of Cell, Jayachandran et al. (2007) suggest that mycobacteria co-opt the actin-binding protein coronin 1 to activate the phosphatase calcineurin, thereby preventing phagosomal maturation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcineurin / metabolism
  • Calcium / metabolism*
  • Calcium Signaling / physiology*
  • Humans
  • Lysosomes / metabolism
  • Macrophages / cytology
  • Macrophages / metabolism*
  • Macrophages / microbiology
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism
  • Mycobacterium tuberculosis / metabolism*
  • Mycobacterium tuberculosis / pathogenicity
  • Phagosomes* / metabolism
  • Phagosomes* / microbiology
  • Tuberculosis

Substances

  • Microfilament Proteins
  • coronin proteins
  • Calcineurin
  • Calcium