Objective: To observe the changes of thromboxane B2 (TXB2), rennin, angiotensin II (AT-II), endothelin 1 (ET-1) and anticardiolipin antibody (ACA) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after the operation.
Method: Fifty-four cases of OSAHS confirmed by polysomnography (PSG) were selected as the OSAHS group and 20 normal donors without OSAHS were selected as the control group. Plasma levels of TXB2, rennin, AT- II, ET-1 and ACA were detected by enzyme-linked immunosorbent assay (ELISA).
Result: Plasma levels of TXB2, rennin, AT-II, ET-1 and ACA were higher in patients with OSAHS than those in control group (P < 0.05 or P < 0.01), and the operation therapy decreased them significantly (P < 0.05 or P <0.01). All the plasma parameters were correlated positively with AHI, and negatively with SaO2.
Conclusion: The results indicate the patients with OSAHS were susceptible to thromboembolism disease. Operation therapy is effective in correcting TXB2, rennin, AT-II, ET-1 and ACA.