Abstract
Osteopontin (OPN) is a secreted adhesive glycophosphoprotein expressed by several cell types. It is normally produced in bone, teeth, kidney and epithelial lining tissues and is found in plasma and breast milk. It is involved in a number of physiologic and pathologic events including angiogenesis, apoptosis, inflammation, wound healing and tumor metastasis. In this review focus will be on OPN in bone and its role in adhesion, migration and cell survival. These aspects of OPN biology are important in tumorigenesis.
MeSH terms
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Adenocarcinoma / etiology
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Adenocarcinoma / metabolism
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Adenocarcinoma / secondary
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Apoptosis
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Bone Neoplasms / etiology
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Bone Neoplasms / metabolism
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Bone Neoplasms / secondary
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Bone and Bones / cytology
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Bone and Bones / metabolism*
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Breast Neoplasms / complications
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Cell Adhesion
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Cell Movement
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Cell Survival
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Cell Transformation, Neoplastic / metabolism
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Chemotaxis
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Female
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Humans
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Integrins / metabolism
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Male
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Multiple Myeloma / complications
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Multiple Myeloma / metabolism
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Neoplasm Proteins / physiology
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Osteoclasts / metabolism
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Osteoclasts / pathology
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Osteolysis / etiology
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Osteopontin
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Prostatic Neoplasms / metabolism
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Prostatic Neoplasms / pathology
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Sialoglycoproteins / physiology*
Substances
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Integrins
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Neoplasm Proteins
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SPP1 protein, human
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Sialoglycoproteins
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Osteopontin