Abstract
Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adult
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Child
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Chromosomes, Human, X
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Chromosomes, Human, Y
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Female
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Graft vs Host Disease / therapy*
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Haploidy
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Humans
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Immunosuppression Therapy
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In Situ Hybridization, Fluorescence
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Intestinal Mucosa / ultrastructure
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Lymphocyte Culture Test, Mixed
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Male
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Mesenchymal Stem Cell Transplantation*
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Mesenchymal Stem Cells / immunology
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Transplantation Chimera
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Transplantation, Homologous