The bone marrow leaves its scar: new concepts in pulmonary fibrosis

J Clin Invest. 2004 Jan;113(2):180-2. doi: 10.1172/JCI20782.

Abstract

Excess collagen deposition occurs in pulmonary fibrosis. A new study suggests that collagen overproduction may originate from cells derived from bone marrow precursors rather than parenchymal lung fibroblasts.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Bleomycin / pharmacology
  • Bone Marrow Cells / pathology*
  • Cell Lineage
  • Collagen / metabolism
  • Fibroblasts / metabolism
  • Fibrosis / pathology*
  • Hematopoietic Stem Cells / cytology
  • Humans
  • Lung / pathology*
  • Models, Biological
  • Pulmonary Fibrosis / pathology*
  • Stem Cells / metabolism

Substances

  • Bleomycin
  • Collagen