T cells and eosinophils in the pathogenesis of asthma

C J Corrigan; A B Kay

doi:10.1016/0167-5699(92)90026-4

T cells and eosinophils in the pathogenesis of asthma

Immunol Today. 1992 Dec;13(12):501-7. doi: 10.1016/0167-5699(92)90026-4.

Authors

C J Corrigan¹, A B Kay

Affiliation

¹ Dept of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK.

PMID: 1361126
DOI: 10.1016/0167-5699(92)90026-4

Abstract

Persistent asthma is characterized by chronic inflammation of the bronchial mucosa, where T cells and eosinophils are prominent. This article summarizes the evidence that asthmatic bronchial inflammation is initiated and propagated by cytokines secreted by activated T cells and other cells, and describes how the release of specific cytokines could result in local preferential accumulation and activation of eosinophils.

Publication types

Review

MeSH terms

Asthma / etiology
Asthma / physiopathology*
CD4-Positive T-Lymphocytes / physiology
Cytokines / physiology
Eosinophils / immunology*
Gene Expression
Granulocyte-Macrophage Colony-Stimulating Factor / genetics
Humans
Immunoglobulin E / physiology
Inflammation / physiopathology
Mucous Membrane / physiopathology
RNA, Messenger / genetics
T-Lymphocytes / immunology*
T-Lymphocytes, Helper-Inducer / immunology

Substances

Cytokines
RNA, Messenger
Immunoglobulin E
Granulocyte-Macrophage Colony-Stimulating Factor