The effects of respiratory motion and imaging at low tidal volumes can easily obscure normal anatomy as well as pathology on high-resolution computed tomography (HRCT) images of the lungs in infants and young children. The benefits of motion-free HRCT in children at full inflation and end exhalation compared with HRCT during quiet breathing has remained largely unexplored. The authors describe the application and benefits of a physiologic, noninvasive technique called controlled-ventilation to obtain high-quality HRCT images of the lungs, similar to those obtained in adults, in uncooperative young children. The availability of this method should result in greater application of HRCT as a clinical and research tool in the evaluation of childhood respiratory disease.