Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci

W O Cookson; B Ubhi; R Lawrence; G R Abecasis; A J Walley; H E Cox; R Coleman; N I Leaves; R C Trembath; M F Moffatt; J I Harper

doi:10.1038/86867

Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci

Nat Genet. 2001 Apr;27(4):372-3. doi: 10.1038/86867.

Authors

W O Cookson¹, B Ubhi, R Lawrence, G R Abecasis, A J Walley, H E Cox, R Coleman, N I Leaves, R C Trembath, M F Moffatt, J I Harper

Affiliation

¹ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. william.cookson@ndm.ox.ac.uk

PMID: 11279517
DOI: 10.1038/86867

Abstract

We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Dermatitis, Atopic / genetics*
Genetic Linkage*
Genetic Predisposition to Disease*
Humans
Psoriasis / genetics*