Oxidative Stress and Antioxidants in Exercise

C.      Leeuwenburgh; J.   W.   Heinecke

Abstract

Increased aerobic metabolism during exercise is a potential source of oxidative stress. In muscle, mitochondria are one important source of reactive intermediates that include superoxide,hydrogen peroxide, and possibly hydroxyl radical . The recent discovery that mitochondria may generate nitric oxide also has implications for oxidant production and mitochondrial function. In this review, we critically examine the concept that production of reactive intermediates increases during exercise. Because the health benefits of regular exercise are well-documented, we also examine adaptations to exercise that may decrease oxidative stress. These include increased antioxidant defenses, reduced basal production of oxidants, and reduction of radical leak during oxidative phosphorylation.

Keywords: Oxidative Stress, Antioxidants, hydrogen peroxide, nitric oxide, Electron Spin Resonance, Gas Chromatography-Mass Spectrometry

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Current Medicinal Chemistry

Title: Oxidative Stress and Antioxidants in Exercise

Volume: 8 Issue: 7

Author(s): C. Leeuwenburgh and J. W. Heinecke

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Keywords: Oxidative Stress, Antioxidants, hydrogen peroxide, nitric oxide, Electron Spin Resonance, Gas Chromatography-Mass Spectrometry

Abstract: Increased aerobic metabolism during exercise is a potential source of oxidative stress. In muscle, mitochondria are one important source of reactive intermediates that include superoxide,hydrogen peroxide, and possibly hydroxyl radical . The recent discovery that mitochondria may generate nitric oxide also has implications for oxidant production and mitochondrial function. In this review, we critically examine the concept that production of reactive intermediates increases during exercise. Because the health benefits of regular exercise are well-documented, we also examine adaptations to exercise that may decrease oxidative stress. These include increased antioxidant defenses, reduced basal production of oxidants, and reduction of radical leak during oxidative phosphorylation.

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Leeuwenburgh C. and Heinecke W. J., Oxidative Stress and Antioxidants in Exercise, Current Medicinal Chemistry 2001; 8 (7) . https://dx.doi.org/10.2174/0929867013372896

DOI https://dx.doi.org/10.2174/0929867013372896	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X

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