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Antibiotic hypersensitivity in patients with CF

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Abstract

Antibiotic hypersensitivity reactions are relatively common in patients with cystic fibrosis (CF). The nature of the reactions and the mechanisms are no different in CF than the general population. Beta-lactam agents are the most common cause of these reactions. The risk depends on the specific betalactam agent used with Penicillins having a higher frequency of allergic reactions. There are several risk factors for developing these allergic responses, especially the increased usage. Since the available choices for antibiotic therapy is limited by the sensitivity of the organisms, management becomes a challenge. It is essential to classify the nature of the hypersensitivity reactions and determine the risks of repeat administration of the drug. Unfortunately, reliable skin tests are not available for all the antibiotics. RAST is of limited value. Recent data on cross-reactions between beta-lactam antibiotics and the option of newer agents offer useful alternative choices. Knowledge of the chemical structures of the antibiotics is useful for selecting suitable substitutes. Desensitization is a viable option in many of the reactions unless otherwise contradicted.

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References

  1. Wills, R., Henry, R.L., and Francis, J.L. (1998), J. Paediatr. Child Health 34, 325–329.

    Article  PubMed  CAS  Google Scholar 

  2. Koch, C., Hjelt, K., Pedersen, S.S., Jensen, E.T., Jensen, T., Lanng, S., et al. (1991), Rev. Infect. Dis. 13(suppl 17), S608-S611.

    PubMed  Google Scholar 

  3. Stead, R.J., Kennedy, H.G., Hobson, M.E., and Batten, J.C. (1985), Thorax 40, 184–186.

    PubMed  CAS  Google Scholar 

  4. Pleasants, R.A., Walker, T.R., and Samuelson, W.M. (1994), Chest 106, 1124–1128.

    Article  PubMed  CAS  Google Scholar 

  5. Parker, C.W., Shapiro, J., Kern, M., and Eisen, H.N. (1962), J. Exp. Med. 115, 821–838.

    Article  PubMed  CAS  Google Scholar 

  6. Moss, R.B. (1989), J. Allergy Clin. Immunol. 83(6), 1138.

    Article  PubMed  CAS  Google Scholar 

  7. Sogn, D.D. (1986), J. Allergy Clin. Immunol. 78(suppl 5), 1051–1052.

    Article  PubMed  CAS  Google Scholar 

  8. Warner, J.O., Taylor, B.W., Norman, A.P., and Soothill, J.F. (1976), Arch. Dis. Child. 51, 507–511.

    PubMed  CAS  Google Scholar 

  9. Pitcher-Wilmott, R.W., Levinsky, R.J., Gordon, I., Turner, M.W., and Matthew, D.J. (1982), Arch. Dis. Child. 57(8), 582–586.

    PubMed  CAS  Google Scholar 

  10. McDonnel, T.J. and Fitzgerald, M.X. (1984), Lancet 1, 301–302.

    Google Scholar 

  11. Saxon, A., Adelman, D.C., Patel, A., Hajdu, R., and Calandra, G.B. (1988), J. Allerg. Clin. Immunol. 82, 213–217.

    Article  CAS  Google Scholar 

  12. Erffmeyer, J.E. (1981), Ann. Allergy 47, 288–300.

    PubMed  CAS  Google Scholar 

  13. Idsoe, O., Guthe, T., Willcox, R.R., and de Weck, A.L. (1994), Bull. WHO 38(2), 159–188.

    Google Scholar 

  14. Rourk, M. and Spock, A. (1970), CF Club Abstr., 20.

  15. Agostini, M., Barlocco, G., Bonomi, U., Capelletti, L.J., Castellani, L., Conforti, M., et al. (1984), Drugs. Exp. Clin. Res. 8/9, 671–686.

    Google Scholar 

  16. Young, E.J., Fainstein, V., and Musher, D.M. (1982), Rev. Infect. Dis. 4, 69–77.

    PubMed  CAS  Google Scholar 

  17. Ghosal, S. and Taylor, C.J. (1997), J. Antimicrob. Chemother. 39, 556–557.

    Article  PubMed  CAS  Google Scholar 

  18. Kishiyama, J.L. and Adelman, D.C. (1994), Drug Saf. 10, 318–327.

    PubMed  CAS  Google Scholar 

  19. Girard, J.P. (1968), Int. Arch. Allergy 33, 428–438.

    PubMed  CAS  Google Scholar 

  20. Saxon, A., Beall, G.N., Rohr, A.S., and Adelman, D.C. (1987), Ann. Intern. Med. 107, 204–215.

    PubMed  CAS  Google Scholar 

  21. Adkinson Jr., N.F., Swabb, E.A., and Sugerman, A.A. (1984), Antimicrob. Agents Chemoth. 25, 93–97.

    CAS  Google Scholar 

  22. Adkinson Jr., N.F., Saxon, A., Spence, M.R., and Swabb, E.A. (1985), Rev. Infect. Dis. 7, S613–621.

    Google Scholar 

  23. Adkinson Jr., N.F. (1990), Am. J. Med. 88(suppl 3C), 12S-15S.

    PubMed  Google Scholar 

  24. Vega, J.M. and Blanca, M. (1991), Allergy 46, 196–202.

    Article  PubMed  CAS  Google Scholar 

  25. Jensen, T., Pedersen, S.S., Nielsen, C.H., Hoiby, N., and Koch, C. (1987), J. Antimicrob. Chemother. 20, 585–594.

    Article  PubMed  CAS  Google Scholar 

  26. Moss, R.B., Babin, S., Blessing, J., and Lewiston, N.J. (1984), J. Pediatr. 104, 460–466.

    Article  PubMed  CAS  Google Scholar 

  27. Shepherd, G.M. (1992), Immunol. Allerg. Clin. North Am. 1, 611–633.

    Google Scholar 

  28. Audicana, M., Bernaola, G., Urrutia, I., et al., (1994), Allergy 49, 108–113.

    Article  PubMed  CAS  Google Scholar 

  29. Blanca, M., Perez, E., Garcia, J., et al. (1988), Allergy 43, 508–510.

    Article  PubMed  CAS  Google Scholar 

  30. Miranda, A., Blanca, M., Vega, J.M., Garcia, J., et al. (1996), J. Allerg. Clin. Immunol. 98, 671–677.

    Article  CAS  Google Scholar 

  31. Sastre, J., Quijano, L.D., Novalbos, A., et al. (1996), Allergy 51, 383–386.

    Article  PubMed  CAS  Google Scholar 

  32. Novalbos, A., Sastre J., Cuesta J., De Las Heras M., Lluch-Bernal M., Bombin C., et al. (2001), Clin. Exp. Allergy 31, 438–443.

    Article  PubMed  CAS  Google Scholar 

  33. Anne, S. and Reisman, R.E. (1995), Ann. Allergy Asthma Immunol. 74, 161–170.

    Google Scholar 

  34. Blanca, M., Fernandez, M., Miranda, A., et al. (1989), J. Allergy Clin. Immunol. 83, 381–385.

    Article  PubMed  CAS  Google Scholar 

  35. Blanca, M., Vega, J.M., Garcia, J., et al. (1990), Clin. Exp. Allergy 20, 475–481.

    Article  PubMed  CAS  Google Scholar 

  36. Pimiento, A.P., Martinez, M.G., Mena, A.M., Gonzalez, A.T., De Paz Arranz, S., and Mosquera, M.R. (1998), Allergy 53, 624–625.

    Article  Google Scholar 

  37. Dukes, M.N.G. (1992), 12th ed. Amsterdam: Excerpta Medica.

  38. Samsoen, M., Metz, R., Melchior, E., and Fonssereau, J. (1980), Contact Dermatitis 6, 141.

    Article  PubMed  CAS  Google Scholar 

  39. Schorr, W.F. and Hegedus, S.I. (1973), Arch. Dermatol. 107, 533–539.

    Article  PubMed  CAS  Google Scholar 

  40. Forstrom, L. and Pirila, V. (1979), Acta Derm. Venerol. Suppl. (Stockh) 59, 67–69.

    CAS  Google Scholar 

  41. Schorr, W.F. and Ridgway, H.B. (1977), Contact Dermatitis 3, 133–137.

    Article  PubMed  CAS  Google Scholar 

  42. Earl, H.S. and Sullivan, T.J. (1987), J. Allergy Clin. Immunol. 79, 477–483.

    Article  PubMed  CAS  Google Scholar 

  43. Schretlen-Doherty, J. and Troutman, W.G. (1995), Ann. Pharmacother. 29, 704–706.

    PubMed  CAS  Google Scholar 

  44. Burdge, D.R., Nakielna, E.M., and Rabin, H.R. (1995), Antimicrob. Agents Chemother. 39, 793.

    PubMed  CAS  Google Scholar 

  45. Jensen, T., Pedersen, S.S., Hoiby, N., and Koch, C. (1991), Rev. Infect. Dis. 13(suppl 7), S594-S597.

    PubMed  Google Scholar 

  46. Jaffe, A. and Bush, A. (1999), Pediat. Pulmonol. 28, 449–450.

    Article  CAS  Google Scholar 

  47. Davis, H., McGoodwin, E., and Reed, T.G. (1989), Ann. Intern. Med. 111, 1041–1043.

    PubMed  CAS  Google Scholar 

  48. Peters, B. and Pinching, A.J. (1989), Br. Med. J. 298, 605.

    Article  CAS  Google Scholar 

  49. Wurtz, R.M., Abrams, D., Becker, S., et al. (1989), Lancet 1, 955–956.

    Article  PubMed  CAS  Google Scholar 

  50. Miller, M.S., Gaido, F., Rourk Jr., M.H., and Spock, A. (1990), Pediatr. Infect. Dis. J. 10(2), 164–165.

    Google Scholar 

  51. Deamer, R.L., Prichard, J.G., and Loman, G.J. (1992), Ann. Pharmacother. 26, 1081–1084.

    PubMed  CAS  Google Scholar 

  52. Davila, I., Diez, M.L., Quirce, S., Fraj, J., De La Hoz, B., and Lazaro, M. (1993), Allergy 48, 388–390.

    Article  PubMed  CAS  Google Scholar 

  53. Lantner, R.R. (1995), J. Allergy Clin. Immunol. 96, 1001–1002.

    Article  PubMed  CAS  Google Scholar 

  54. Sullivan, T.J. (1982), J. Allergy Clin. Immunol. 69, 500–508.

    Article  PubMed  CAS  Google Scholar 

  55. Weiss, M.E. and Adkinson, N.F. (1988), Clin. Allergy 18, 515–540.

    Article  PubMed  CAS  Google Scholar 

  56. MacGlashan, Jr. D. and Lichtenstein, L.M. (1987), J. Immunol. 139, 501–505.

    PubMed  CAS  Google Scholar 

  57. Sullivan, T.J. (1993), Current Views in Allergy & Immunology, Volume XXI. pp 204–301.

    Google Scholar 

  58. Naclerio, R.N., Mizrahi, E.A., and Adkinson, Jr., N.F. (1983), J. Allergy Clin. Immunol. 71, 294.

    Article  PubMed  CAS  Google Scholar 

  59. Sullivan, T.J. (1993), Allergy Principles and Practice, 4th ed., Mosby, St. Louis, MO.

    Google Scholar 

  60. Borish, L., Tamir, R., and Rosenwasser, L.J. (1987), J. Allergy Clin. Immunol. 80, 314–319.

    Article  PubMed  CAS  Google Scholar 

  61. Gorevic, P.D. and Levine, B.B. (1981), J. Allergy Clin. Immunol. 68, 267–272.

    Article  PubMed  CAS  Google Scholar 

  62. Moss, R.B. (1991), J. Allergy Clin. Immunol. 87, 78–88.

    Article  PubMed  CAS  Google Scholar 

  63. Gruchalla, R.S. (1998), Clin. Exp. Allergy 28 (4), 63–64.

    PubMed  CAS  Google Scholar 

  64. Brown, L.A., Goldberg, N.B., and Shearer, W.T. (1982), J. Allergy Clin. Immunol. 69, 51–54.

    Article  PubMed  CAS  Google Scholar 

  65. Stark, B.J., Earl, H.S., Gross, G.N., Lumry, W.R., Goodman, E.L., and Sullivan, T.J. (1987), J. Allergy Clin. Immunol. 79, 523–532.

    Article  PubMed  CAS  Google Scholar 

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  1. Children's Hospital of Buffalo, State University of New York at Buffalo, 14222, Buffalo, NY

    Sujatha Ramesh

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Ramesh, S. Antibiotic hypersensitivity in patients with CF. Clinic Rev Allerg Immunol 23, 123–142 (2002). https://doi.org/10.1385/CRIAI:23:1:123

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