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Clinical InvestigationsDietary Supplementation and Respiratory Muscle Performance in Patients with COPD
Section snippets
Selection of Patients
Twenty-five ambulatory patients with severe COPD (forced expired volume in one second [FEV1] less than 50 percent of predicted) gave informed consent for study. All patients were in a stable phase of their disease. They did not have an acute exacerbation of their disease in the three months prior to this study or during the study. Patients with a known eating disorder, an infectious process, pulmonary disease other than COPD, lactose intolerance, other medical illness (diabetes mellitus,
Baseline Measurements in All 25 Patients
Mean (± SD) baseline data for the 25 patients are shown in Table 1. There was wide variability in weight as percentage of IBW (range, 61 to 108 percent), with 13 of 25 patients malnourished (<85 percent of IBW). Control daily caloric intake also varied widely between patients (range, 1,100 to 3,112 kcal/day). In all patients, serum albumin, serum transferrin, and blood lymphocyte counts were in the normal range. There was a correlation between body weight and both TSF (r=0.67; p<0.005) and MAMC
DISCUSSION
The major findings in this study of 25 ambulatory patients with severe COPD were that: (1) there was a small increase in body weight with eight weeks of dietary supplementation; (2) there was an inability of some patients to increase daily caloric intake; (3) there was a tendency to lose weight within one month of discontinuation of dietary supplements; (4) there was habituation to tests measuring PImax and PTP with stability of PEmax and SIP, and (5) there was no important change in RM
ACKNOWLEDGMENTS
We thank Ms. S. Gordon, nurse coordinator, and Mrs. P Bouchard, dietician, for their contributions.
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Supported by a grant from Mead Johnson.