Chest
Volume 90, Issue 4, October 1986, Pages 575-577
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Symposium
Airway Inflammation and Airway Hyperresponsiveness

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CELLULAR COMPONENTS OF INFLAMMATION

The initial attempts made to determine the important component of the inflammatory response concentrated on the neutrophil, as this was the most prominent cell seen in both dogs10, 11 and human subjects14 who had developed airway hyperresponsiveness after inhalation of ozone. Dogs were initially depleted of circulating neutrophils, using intravenous hydroxyurea, and were then exposed to ozone. In the neutropenic dogs, ozone exposure did not lead to airway hyperresponsiveness. When the

CHEMICAL MEDIATORS OF INFLAMMATION

Early studies of ozone-induced airway hyperresponsiveness in dogs had demonstrated that the predominant influx of neutrophils was into the epithelial layer of the trachea. This suggested that the epithelium may be the source of the chemotactic factor for neutrophils. Subsequently, Holtzman et al20 demonstrated that isolated epithelial cells from canine airways could convert arachidonic acid to leukotriene B4 (LTB4), which is known to be a potent neutrophil chemotactic factor. 21 When LTB4 is

ACKNOWLEDGMENT

I am grateful to Mrs. L. Rogers for typing this manuscript and to Dr. H. Ramsdale for helpful advice in its preparation.

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    Recipient of a Medical Research Council of Canada Scholarship.

    Publication of this symposium has been made possible by an educational grant from the Schering Corporation.

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