Chest
SymposiumAirway Inflammation and Airway Hyperresponsiveness
Section snippets
CELLULAR COMPONENTS OF INFLAMMATION
The initial attempts made to determine the important component of the inflammatory response concentrated on the neutrophil, as this was the most prominent cell seen in both dogs10, 11 and human subjects14 who had developed airway hyperresponsiveness after inhalation of ozone. Dogs were initially depleted of circulating neutrophils, using intravenous hydroxyurea, and were then exposed to ozone. In the neutropenic dogs, ozone exposure did not lead to airway hyperresponsiveness. When the
CHEMICAL MEDIATORS OF INFLAMMATION
Early studies of ozone-induced airway hyperresponsiveness in dogs had demonstrated that the predominant influx of neutrophils was into the epithelial layer of the trachea. This suggested that the epithelium may be the source of the chemotactic factor for neutrophils. Subsequently, Holtzman et al20 demonstrated that isolated epithelial cells from canine airways could convert arachidonic acid to leukotriene B4 (LTB4), which is known to be a potent neutrophil chemotactic factor. 21 When LTB4 is
ACKNOWLEDGMENT
I am grateful to Mrs. L. Rogers for typing this manuscript and to Dr. H. Ramsdale for helpful advice in its preparation.
REFERENCES (29)
- et al.
Bronchial responsiveness to inhaled histamine or methacholine in asthma: measurement and clinical significance
J Allergy Clin Immunol
(1981) - et al.
Clinical features and natural history of occupational asthma due to Western red cedar (Thuja plicata)
Am J Med
(1982) - et al.
Effect of bronchial lavage volume on cellulal and protein recovery
Chest
(1985) - et al.
Selective generation of leukotriene B4 by tracheal epithelial cells from dogs
Biochem Biophys Res Commun
(1983) - et al.
An anti-inflammatory drug (BW 755c) inhibits airway hyperresponsiveness induced by ozone in dogs
J Allergy Clin Immunol
(1985) Inhibition of the late asthmatic response to house dust mite by non-steroidal anti-inflammatory drugs
Prostagland Leuk Med
(1982)- et al.
Airway responsiveness to histamine and methacholine; relationship to minimum treatment to control symptoms of asthma
Thorax
(1981) - et al.
Long term stability of bronchial responsiveness to histamine
Thorax
(1982) - et al.
Allergen-induced increases in non-allergic bronchial reactivity
Clin Allergy
(1977) - et al.
Bronchial hyperirritability in healthy subjects after exposure to ozone
Am Rev Respir Dis
(1978)
Mechanisms of bronchial hyperreactivity in norman subjects after upper respiratory tract infection
Am Rev Respir Dis
Effect of ozone on bronchomotor response to inhaled histamine aerosol in dogs
J Appl Physiol
Time course of airway hyperresponsiveness induced by ozone in dogs
J Appl Physiol
Importance of airway inflammation for hyperresponsiveness induced by ozone
Am Rev Respir Dis
Cited by (46)
Mild Asthma and Life-Threatening Exacerbations: Is it Time to Take Action?
2020, Archivos de BronconeumologiaAffirmation of the adoration of the vagi and role of tiotropium in asthmatic patients
2016, Journal of Allergy and Clinical ImmunologyPrevention of exercise-induced asthma by a natural isomer mixture of β- carotene
1999, Annals of Allergy, Asthma and ImmunologyEffectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness
1995, Pharmacological Research
Recipient of a Medical Research Council of Canada Scholarship.
Publication of this symposium has been made possible by an educational grant from the Schering Corporation.