Chest
Clinical InvestigationsDirect-Writing Recorder of the Dose-Response Curves of the Airway to Methacholine: Clinical Application
Section snippets
MATERIALS AND METHODS
We studied ten normal subjects (all men, nine nonsmokers and one smoker; mean age, 30 years) without cardiopulmonary disease and without any allergy history or family history of allergy; 14 patients with acute bronchitis (eight men and six women; mean age, 44 years); 16 patients with chronic bronchitis (eight men and eight women; mean age, 48 years); and 60 patients with extrinsic asthma (36 men and 24 women; mean age, 42 years). Chronic bronchitis was diagnosed on the basis of the clinical
Results
Figure 2 shows the dose-response curve in a patient with bronchial asthma. In bronchial asthma after the Rrs remained at an almost constant value for a short period, it increased curvilinearly after a threshold concentration of methacholine and decreased rapidly after the inhalation of metaproterenol. In general, the patterns in the cases of bronchial asthma were similar to isosceles triangles. On the other hand, in the normal subjects, the Rrs did not increase up to the maximum concentration
Validity of the Method
The bronchial provocation test is widely used, not only for examining the bronchial responsiveness in various pulmonary disease, but also for diagnosing bronchial asthma; however, since the method of examination has not yet been established, each investigator uses his own method. Therefore, the comparison of data among different laboratories has been difficult. Recently Chai et al3 reported the standardizations of the procedures for bronchial inhalation challenge for antigen, methacholine, and
ACKNOWLEDGEMENT
We wish to express our gratitude for the measurement of particle sizes of nebulizers to Mr. H. Shimizu, T. Kobayashi, and H. Inaba, Tohoku University School of Technology, and for the preparation of this report to Mr. P. Cantor, Ms. K. Toda, and Ms. S. Omori.
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