Chest
Chronic Lung Damage Caused by Adenovirus Type 7: A Ten-Year Follow-up Study
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MATERIAL AND METHODS
The study population consisted of 27 children (seven girls and 20 boys) with adenovirus type 7 pneumonia, treated in the Department of Pediatrics, University of Oulu, from January 1967 to December 1968. Ages, diagnostic criteria, clinical manifestations, laboratory findings, and roentgenologic pulmonary changes of 25 of these children have been described earlier.7 Two additional children, a girl and a boy, aged seven years and three months, respectively, treated in the same hospital during 1976
RESULTS
Abnormal chest roentgenogram was demonstrated in 12 of the 22 children (Table 1). Of those 12 patients, eight were selected for subsequent bronchography. Bronchiectasis was demonstrated with contrast medium in four patients (Table 2, cases 1 to 4). In two additional patients, bronchiectasis had been diagnosed earlier (cases 5 and 6, Table 2). One of them (case 6) had chronic pulmonary disease with a normal α1-antitrypsin serum level with genotype PiMZ. Lobectomy of the upper right lobe and
DISCUSSION
Several adenoviruses, especially types 1, 3, 4, 7, and 21, can cause serious pneumonia.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 The clinical syndrome of adenovirus pneumonia has been summarized by James et al13 as follows: cough, dyspnea, wheeze, and fever occur during the week of onset in children who are mostly under the age of three years, often under 18 months. Roentgenograms show widespread patchy or confluent pulmonary opacification, extensive bronchial wall thickening, and streaky
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This work was supported by the Tuberculosis Foundation of Tampere, Finland.