Chest
Original ResearchPlasma Adhesion Molecules in Children With Sleep-Disordered Breathing
Section snippets
Materials and Methods
Children were recruited to this study from two sources: children undergoing clinical evaluation for suspected SDB who were referred to the Kosair Children's Hospital Sleep Medicine and Apnea Center in Louisville, KY, and those children participating in a larger community-based study in Louisville, KY. The latter community group provided control children. All children were recruited between January and August of 2004. All subjects underwent a standard overnight polysomnographic evaluation and a
Results
A total of 128 children (51% male) underwent polysomnographic evaluation with a morning blood draw. The mean age of the population was 6.9 ± 1.2 years (range, 4.0 to 10.0 years). Sixty percent of the samples were white, 37% were African American, and 4% were of other ethnic backgrounds. A total of 39 children were found to have SDB (AHI > 5/h), 47 children had mild SDB, and 42 children were classified as control subjects (AHI < 1/h). All of the control children were recruited from the community
Discussion
This study conclusively demonstrates that children with SDB have elevated circulating levels of plasma P-selectin, a surface marker of platelet activation, and that P-selectin is correlated with components of SDB, namely the severity of oxyhemoglobin desaturation and the respiratory arousal index. Our current findings suggest that inflammatory processes associated with atherogenesis and leading to activation of P-selectin are elicited by SDB in children. Interestingly, although elevated ICAM-1
Acknowledgment
We are grateful to the parents and children who participated in this study and to the technical staff who performed the polysomnography.
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2015, Sleep Medicine ReviewsCitation Excerpt :When the authors used AHI, the AHI ranged from AHI >1 to AHI >5/hrTST. Most of the studies assessed blood biomarkers [41–44,46,49–52,54–57,59–62,66–68,74], while seven studied urinary biomarkers [47,48,53,58,63,64,73], four explored for potential biomarkers in saliva [69–72], and three studies involved EBC [45,65,75]. A summary of the study descriptive characteristics can be found in Table 1.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
Dr. Tauman was supported by an Ohio Valley AHA Fellowship.
This study was supported by National Institutes of Health Grant HL-65270, Department of Education Grant H324E011001, Centers for Disease Control and Prevention Grant E11/CCE 422081–01, The Children's Foundation Endowment for Sleep Research, and the Commonwealth of Kentucky Research Challenge Trust Fund.