Chest
Original Research: AsthmaProtective Effect of Fish Oil Supplementation on Exercise-Induced Bronchoconstriction in Asthma
Section snippets
Subjects
Sixteen subjects (10 men and 6 women; mean age ± SD, 23 ± 1.6 years; body mass index, 23.05 ± 2.2 kg/m2 [normal diet]) with both physician-diagnosed asthma and documented EIB were recruited from a population of university students and the local community and indicated they were recreationally active. All subjects had clinically treated mild-to-moderate persistent asthma, with an FEV1 > 70% of predicted.14 A group of nonasthmatic (control) subjects was not included in the present study, as it
Subjects
Bronchodilator use (total number of doses/puffs) was significantly reduced (p < 0.05) during the last 2 weeks of the fish oil diet (45 puffs; 95% CI, 34 to 51 puffs) compared to the normal diet (61 puffs; 95% CI, 53 to 68 puffs) and placebo diet (65 puffs; 95% CI, 56 to 72 puffs). There was no significant difference (p > 0.05) in bronchodilator use between the normal and placebo diets. A 2 × 2 ANOVA that was used to test for the presence of carryover effects between diets indicated that none
Discussion
This study has demonstrated that a diet supplemented with fish oil ameliorates the severity of exercise-induced airway narrowing in subjects with mild-to-moderate persistent asthma. The fish oil diet improved pulmonary function to below the diagnostic EIB threshold of a 10% fall in postexercise FEV1, and reduced the fall in FEV1 at 15 min after exercise by approximately 64%. This improvement in postexercise pulmonary function on the fish oil diet was accompanied by a > 31% reduction in
References (43)
- et al.
Exercise-induced asthma: is it the right diagnosis in elite athletes?
J Allergy Clin Immunol
(2000) - et al.
The mechanism of exercise-induced asthma is
J Allergy Clin Immunol
(2000) - et al.
A validated liquid chromatography-mass spectrometry method for the determination of leukotrienes B4and B5produced by stimulated human polymorphonuclear leukocytes
Anal Biochem
(2005) - et al.
Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production
Am J Clin Nutr
(1997) - et al.
Leukotriene E4and granulocytic infiltration into asthmatic airways
Lancet
(1993) - et al.
Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5and the double lipoxygenase product
J Biol Chem
(1984) - et al.
Eosinophil influx into the airways in patients with exercise-induced asthma
Respir Med
(2000) - et al.
Exercise-induced bronchoconstriction: pathogenesis
Curr Allergy Asthma Rep
(2005) - et al.
Postexertional airway rewarming and thermally induced asthma
J Clin Invest
(1986) - et al.
Diet and asthma
Am J Respir Crit Care Med
(2004)
Dietary components with demonstrated effectiveness in decreasing the severity of exercise-induced asthma
Sports Med
Dietary fat and asthma: is there a connection?
Eur Respir J
Omega-3 fatty acids in inflammation and autoimmune diseases
J Am Coll Nutr
Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids onin vitroneutrophil and monocyte leukotriene generation and neutrophil function
N Engl J Med
The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells
N Engl J Med
Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes
Am J Respir Crit Care Med
Dietary marine fatty acids (fish oil) for asthma in adults and children
Cochrane Database Syst Rev
Effect of dietary supplementation with fish oil lipids on mild asthma
Thorax
American Thoracic Society guidelines for methacholine and exercise challenge testing-1999
Am J Respir Crit Care Med
Standardization of spirometry, 1994 update
Am J Respir Crit Care Med
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