Chest
Clinical InvestigationsCOPDPredictors of Survival in Severe, Early Onset COPD
Section snippets
Study Participants
The recruitment of participants with severe, early onset COPD was performed in three phases. Details of the 44 probands in phase 1 (September 1994 to October 1996) and the 40 probands in phase 2 (January 1998 to June 1999) have been reported previously.16,18 Fifty-five additional probands were recruited in phase 3 (June 1999 to July 2002). In all three phases, participants with severe, early onset COPD were enrolled primarily from the lung transplant and LVRS programs at Brigham and Women’s
Baseline Characteristics of Early Onset COPD Subjects
A total of 139 probands were enrolled in the three phases of the study (Table 1). Details of the demographics and spirometry of the first 84 probands (phases 1 and 2) have been previously reported.16,18 The female predominance noted through the first two phases (71.4% women) persisted in the third phase (74.6% women), and both of these values are significantly different than the predicted equal sex distribution (p < 0.0001 [phases 1 and 2]; p = 0.0003 [phase 3]). Overall, women make up 72.7% of
Discussion
Since the 1960s, multiple studies have investigated the risk factors that influence mortality in a variety of populations of COPD patients. In the current report, we examined the survival of a unique cohort of subjects with severe early onset COPD. The most striking finding was that two separate measures of cigarette smoking had the strongest effect on outcome. The number of pack-years smoked prior to study enrollment as well as smoking during the follow-up period were both independent
ACKNOWLEDGMENT
We thank Ms. Kimberly Ladouceur for her tremendous assistance with recruitment and follow-up of the study subjects, and Drs. Harold Chapman, Frank Speizer, and Scott Weiss for their support and participation throughout all phases of the Boston Early-Onset COPD Study and for their helpful advice regarding this manuscript. We appreciate the assistance of many physicians in recruiting study participants. We are especially thankful for the enthusiastic support from the members of the early onset
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Dr. Silverman has received research grant support from GlaxoSmithKline. This research was supported by National Institutes of Health grants T32-HL07427 (training grant) and HL61575 (EKS).