Chest
Clinical InvestigationsSARCOIDOSISVascular Endothelial Growth Factor Gene Polymorphisms in Japanese Patients With Sarcoidosis
Section snippets
Subjects
One hundred three patients were recruited from the clinic at the Niigata University Hospital. Sarcoidosis was diagnosed on the basis of the typical features and the presence of epithelioid cell granulomas in biopsy specimens from the lung, skin, or lymph nodes. Forty-one of the patients were men, and 62 were women. All patients in the study were Japanese. The average age of patients at diagnosis was 45.1 years (range, 19 to 74 years). One hundred forty-six healthy subjects who had requested
Results
Allele frequencies and genotypes for VEGF SNPs are summarized in Table 3. The genotype frequencies were in agreement with the Hardy-Weinberg equilibrium (p > 0.1 for all analyses). As for − 627 genotypes, of the 103 patients with sarcoidosis, 41 patients had the CC genotype (39.8%), 43 patients had the CG genotype (41.8%), and 19 patients had the GG type (18.4%). The frequency of C allele was 60.7%. Of the 146 healthy control subjects, 51 subjects were type CC (34.9%), 60 subjects were type CG
Discussion
In this study, we investigated two VEGF SNPs to see whether the polymorphisms are associated with susceptibility to sarcoidosis in the Japanese population. We found a significant difference in the allele frequency at locus + 813 between healthy control subjects and patients with sarcoidosis. Compared with the most common C allele, the less common T allele was underrepresented in the sarcoidosis patient population, suggesting that polymorphism at + 813 is associated with decreased risk for
ACKNOWLEDGMENT
The authors thank Ms. Takeuchi and Ms. Ikeda for help in extracting DNA from clinical specimens.
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