Proteinuria in COPD Patients With and Without Respiratory Failure

doi:10.1378/chest.123.2.652

Chest

Volume 123, Issue 2, February 2003, Pages 652-653

https://doi.org/10.1378/chest.123.2.652 Get rights and content

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To the Editor:

We read with great interest the article by Abid et al (December 2001),¹ demonstrating the predictive value of microalbuminuria in the identification of more severe ICU patients. Microalbuminuria is reported to be an early feature of acute inflammatory conditions due to the rapid increase in renal permeability induced by inflammatory mediators and oxygen free radicals. In our opinion, hypoxemia also could play a role on capillary endothelial permeability as shown by much research, both in vivo

REFERENCES (5)

O Abid et al.
Predictive value of microalbuminuria in medical ICU patients
Chest
(2001)
SF Yan et al.
Hypoxia-induced modulation of endothelial cell properties: regulation of barrier-function and expression of interleukin-6
Kidney Int
(1997)

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Cited by (11)

Renal failure in high altitude: Renal functions, renal pathology and bone mineralization in rats with ablation nephropathy at 1200 m altitude
2007, Pathology Research and Practice
The effect of altitude on renal failure and bone mineralization is not well known. This topic is studied in a 5/6 nephrectomy rat model. After hemoglobin, creatinine clearance and proteinuria were determined in 28 Wistar rats. Two 5/6 nephrectomy (Nx1–Nx2, n=7 each) and two sham (Sh1–Sh2, n=7 each) groups were formed. The Nx1–Sh1 and Nx2–Sh2 groups were kept at sea level and at 1200 m altitude, respectively. The same analyses were performed after 3 months just before sacrifices in order to harvest kidneys and femurs for histopathologic examination.
Hemoglobin, creatinine clearance, and proteinuria were similar in all groups at the onset. Final hemoglobin was higher in Nx2–Sh2, but only Sh2 vs. Sh1 was significant (p=0.001). Creatinine clearance decreased (p=0.001 for Nx1) and proteinuria increased (p=0.002 for Nx1 and p=0.005 for Nx2) after 5/6 nephrectomy, but Nx1 vs. Nx2 was similar. Histopathological changes in the remnant kidneys were prominent, but Nx1 vs. Nx2 was not different. Although the relative osteoid volume increased in Nx groups, only Nx1 vs. Sh1 was different (p=0.006).
In conclusion, exposure to 1200 m altitude, compared to the sea level, preserved the creatinine clearance better in 5/6 nephrectomized rats. No change was observed in proteinuria, renal histopathology, and bone mineralization.
Microalbuminuria on admission for acute exacerbation of COPD as a predictor of all-cause mortality and future exacerbations
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Study the association of chronic obstructive pulmonary disease with early endothelial dysfunction and its impact on cardiovascular system by estimating urinary albumin creatinine ratio
2017, Lung India
Microalbuminuria in subjects with COPD: Relationship to the new version of global initiative for chronic obstructive lung disease staging
2017, Respiratory Care
Factors related to microalbuminuria in patients with chronic obstructive pulmonary disease
2014, Advances in Clinical and Experimental Medicine
COPD and microalbuminuria: A 12-year follow-up study
2014, European Respiratory Journal

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Communications to the EditorProteinuria in COPD Patients With and Without Respiratory Failure

Section snippets

To the Editor:

Chest

Kidney Int

Communications to the Editor
Proteinuria in COPD Patients With and Without Respiratory Failure