Chest
Clinical InvestigationsAsthmaDo Inhaled Corticosteroids Affect Perception of Dyspnea During Bronchoconstriction in Asthma?
Section snippets
Patients
One hundred asthma patients (65 women) aged 16 to 75 years (mean age, 41.5 years) diagnosed with bronchial asthma according to the criteria of the National Heart, Lung, and Blood Institute16 participated in the study. In all patients, asthma was stable and persistent, and it was classified as either mild or mild to moderate according to the frequency of symptoms, the requirement of β2-agonists for the treatment of symptoms, baseline airway function, BHR, and a provocative concentration of
Results
Anthropometric, clinical, baseline function, and sputum data of the four groups of patients are listed in Table 1, Table 2. Groups were matched (χ2 analysis) for age, gender, atopy, and clinical score. Groups I and III also were matched for duration of the disease, and groups II and IV were matched for duration of the disease and the daily dosage of ICSs. In groups II and IV, the duration of the disease was significantly higher than that in groups I and III.
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2011, Respiratory MedicineCitation Excerpt :It is possible therefore that an improvement in operating length of the respiratory muscles (particularly the diaphragm) together with improved airway conductance, contributed to the ability of our patients to exercise for a longer duration without a significant increase in dyspnea. It is also possible, but unproven, that topical FP500 (via genomic or non-genomic mechanisms) can modulate respiratory sensation, independent of changes in airway function, by altering afferent activity from sensory receptors in the airway mucosa, as has been postulated in asthma.45,46 Havercamp et al.15 have described consistent improvements in arterial oxygenation in asthmatics following ICS monotherapy which contributed to improvements in exercise performance.
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2011, Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice, Fourth EditionPerception of dyspnea during acetylcholine-induced bronchoconstriction in asthmatic children
2009, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :Ottanelli et al11 reported that eosinophilic inflammation of the airway wall may result in a lowered perception of dyspnea. Corticosteroid inhalation for 8 weeks has been shown to enhance the perception of dyspnea, presumably as a result of its effect in reducing eosinophilic inflammation.12 On the other hand, reduction in the perception of dyspnea has been shown during reduction of the ICS dose, especially during a mild asthma exacerbation.13
This work was supported by grants from the Ministero dell’Università e della Ricerca Scientifica e Tecnologica, Italy, and by the Fondazione Don C. Gnocchi IRCCS.