Chest
Clinical InvestigationsCANCEROutcome of Bronchial Carcinoma In Situ
Section snippets
Materials and Methods
The study population consisted of patients from the Department of Pulmonary Diseases of the University Hospital Vrije Universiteit in Amsterdam, a referral center for endobronchial therapy. The records of all patients who underwent autofluorescence bronchoscopy were reviewed. Indications for autofluorescence bronchoscopy in these patients were as follows: suspected lung cancer, staging of newly diagnosed lung cancer, or follow-up of lung or head and neck cancer. Patients were included in this
Patients
From all 140 patients who underwent autofluorescence bronchoscopy in the period from November 1995 to December 1998, 9 patients fulfilled the inclusion criteria. Patient demographics and bronchoscopy data are shown in Table 1 .
Eight patients were referred to us for assessment of a bronchial carcinoma in situ that was diagnosed by the referring pulmonologist. In five of these patients, the presence of carcinoma in situ was confirmed by pathologists from the Department of Pathology from the
Discussion
Progression to carcinoma was documented in five of nine patients (56%) with a carcinoma in situ. This number might have been greater if no endobronchial therapy had been performed. Two of the four patients without progression to carcinoma were treated with endobronchial therapy. Assuming that without this therapy a carcinoma would have developed, seven of the nine carcinomas (78%) in situ would have progressed to invasive carcinoma. This proportion is greater than the 11% of moderate dysplasias
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