Chest
Selected ReportsAcute Community-Acquired Pneumonia due to Aspergillus in Presumably Immunocompetent Hosts: Clues for Recognition of a Rare but Fatal Disease
Section snippets
Study Data
Previous case reports were identified through a Medline search of the English-language literature from 1966 to the present. Terms searched were: Aspergillus or fungus, and fungal, pneumonia, and immunocompetent. Reports referenced in articles identified through the search also were reviewed.
Case Definition
All cases included in this review fulfilled the following criteria: (1) onset of respiratory symptoms within 14 days of presentation to a health care provider; (2) no underlying medical condition or
Case Report
A 58-year-old previously healthy woman presented to the hospital with a nonproductive cough, fever, and nonspecific flu-like symptoms, starting suddenly 5 days prior to admission. These symptoms did not respond to treatment with clarithromycin. She had no significant past medical history, although she did have a 50 pack-year history of cigarette smoking. She was not taking any medications prior to her illness; she did not smoke marijuana or take other illicit drugs.
Upon admission, laboratory
Discussion
Including this report, only 12 cases of invasive pulmonary aspergillosis presenting as acute community-acquired pneumonia in apparently immunocompetent hosts have been reported in the English-language literature (Table 1).7, 8, 9, 10, 11, 12, 13, 14, 15 All patients were infected with A fumigatus. Patients ranged in age from 14 months to 67 years old (median: 41 years); 6 patients were female. Nine patients were previously healthy, one had chronic obstructive pulmonary disease, one had
Conclusion
Acute community-acquired pneumonia due to Aspergillus is a rare infection in immunocompetent hosts that carries a uniformly fatal prognosis. Aspergillus should be considered as a possible etiologic agent in patients with acute onset of diffuse bilateral pneumonia, cavitary pneumonia, or localized pneumonia rapidly progressing to diffuse pneumonia despite therapy with broad-spectrum antibiotics or with worsening pneumonia following influenza infection. Aspergillus recovered from cultures of
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Association between early diagnosis of and inpatient mortality from invasive pulmonary aspergillosis among patients without immunocompromised host factors: a nationwide observational study
2022, International Journal of Infectious DiseasesCitation Excerpt :BMI was categorized into the following three groups according to the World Health Organization standards: <18.5, 18.5-24.9, and ≥25 kg/m2. We also considered the following underlying IPA comorbidities as covariates on the basis of past reports: COPD (Guinea et al., 2010; Samarakoon and Soubani, 2008), influenza (van de Veerdonk et al., 2017), diabetes (Janes et al., 1998; Komase et al., 2007), and liver cirrhosis (Clancy and Nguyen, 1998; Meersseman et al., 2004). The primary study end point was all-cause inpatient mortality.
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2021, Encyclopedia of Respiratory Medicine, Second EditionInvasive Aspergillosis as a Complication of Influenza Virus H3N2 Infection
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2019, Medecine et Maladies InfectieusesAcute fulminant invasive pulmonary aspergillosis in an immunocompetent host: An autopsy case report
2018, Medical Mycology Case ReportsCitation Excerpt :IPA usually occurs in immunocompromised patients. In rare instances, however, it may affect immunocompetent hosts [1–4] even with no predisposing non-invasive aspergillosis, such as simple aspergilloma or chronic cavity pulmonary aspergillosis. The present case was unique in that acute IPA developed into rapidly progressive respiratory failure.