Chest
Clinical Investigations: MiscellaneousPediatric Reference Values for Respiratory Resistance Measured by Forced Oscillation
Section snippets
MATERIALS AND METHODS
We conducted a cross-sectional study of patients and/or accompanying siblings, aged 3 to 17 years, who presented to the orthopedic clinic or the surgical emergency department of the Montreal Children Hospital, Patients were accrued over two consecutive summers. The protocol was reviewed and approved by the Institutional Review Board and informed consent for participation in the study was obtained from parents or guardians.
RESULTS
During the study period, 1,725 children were screened using the self-administered questionnaire. Of these, 1,443 subjects were excluded because of the following nonmutually exclusive reasons: (1) family history of wheezing or asthma (52%, n = 819); (2) personal history of wheezing or asthma (33%, n=566); (3) personal history of rhinitis or eczema (39%, n=672); and (4) active or passive smoking (59%, n=1,025). Of the remaining 282 subjects, 52 were not approached due to practical reasons such as
DISCUSSION
In this group of 217 carefully selected healthy children, Rfo was closely related to (standing or sitting) height, with 65 to 72% of the variance explained by either stature measurement. After log transformation of height and resistance, neither gender and race were important predictors of resistance. Furthermore, sitting height was not a significantly better predictor of resistance than standing height.
This study presents reference values for Rfo8, Rfo12, and Rfo16 with 5th and 95th
ACKNOWLEDGMENT
We are indebted to the many patients, registration personnel, and the two research nurses (Jacques Lauzon and Francine Proulx) at the Montreal Children's Hospital whose collaboration made this study possible. We thank Michele Gibbon for her data processing, Marie-Claude Guertin for biostatistical assistance, and Judy Fuoco for manuscript preparation.
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2016, Paediatric Respiratory ReviewsCitation Excerpt :Additional parameters, such as the fres, the area under the Xrs-frequency curve below the fres (Figure 2A), the frequency dependence of Rrs, and the reciprocal of Zrs (termed respiratory admittance), are also commonly reported [4,5]. A number of studies have reported results from healthy children in an attempt to establish reference FOT data over a wide range of frequencies [16–25]. Generally, there is significant variability in the reported Rrs and Xrs values, which could be attributed to differences in the characteristics of the examined populations and the equipment and technique used (IOS or pseudorandom noise).
Supported by the McGill University-Montreal Children's Hospital Research Institute and the Medical Research Council (MRC) of Canada.