Chest
Clinical InvestigationsMaintenance of Wakefulness Test and Multiple Sleep Latency Test: Measurement of Different Abilities in Patients With Sleep Disorders
Section snippets
METHODS
We studied a total of 258 patients, 185 men and 73 women, whose mean age was 44.6 (standard deviation = 13.9). Our polysomnographic protocols require that, to the extent that it is medically feasible, all patients should be free, for a minimum of one week prior to sleep laboratory evaluation, of medications that significantly affect the central nervous system. We believe that at least 95 percent of the patients were free of such drugs at the time of study. All had symptoms of daytime sleepiness
RESULTS
Figure 1 shows box plots that summarize the distributions for the individual MWT trials, as well as the four-trial average for each patient. Box plots are useful ways to present truncated data sets such as those resulting when individual scores frequently reach a protocol-dependent maximum such as 20 min for the MSLT and 40 min for the MWT. Each box encompasses the middle 50 percent of the distribution and the horizontal line within the box represents the median. Note that the median for the
DISCUSSION
We have systematically explored the relationship between the MWT and the MSLT in 258 consecutive patients evaluated for excessive daytime sleepiness. Our results indicated a small but significant correlation between the MWT and the MSLT (r = 0.41). While this correlation is statistically significant, it is quite small. The statistical significance is due, of course, to the large number of subjects. In reality, the MWT variance only accounts for about 16 percent of the MSLT variance. This
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Primary funding and support for this project came from the Sleep Disorders Institute of Troy, Michigan.
Supported by PHS grants, R01 NS20459 and R03 AA08235 and by clinical research center grant RR00833 to Scripps Clinic and Research Foundation and by a grant from the American Narcolepsy Association.
Manuscript received May 17; revision accepted July 23.