Chest
The Senile Lung: Comparison with Normal and Emphysematous Lungs 1. Structural Aspects
Section snippets
MATERIAL AND METHODS
Studies were performed on 17 right and 12 left human lungs and one isolated left lower lobe (V50), obtained at autopsy. Lungs were selected on the basis of absence of marked pleural adhesions and leaks, gross parenchymal consolidations, and/or generalized fibrosis. Most lungs were from patients who died of cardiovascular disease or of malignant neoplasms. The examined lungs represent a sample that can be considered unselected at least from the population of patients for whom an autopsy was
RESULTS
The lungs were divided into three groups on the basis of the global aspect of the parenchyma on the whole lung sections (examined by eye and under the dissection microscope) and of the value of Lm. Lungs of group A had a normal aspect, the value of Lm did not exceed 120 percent of expected. In the lungs of groups B and C, the value of Lm was higher than 120 percent. The enlargement of the respiratory airspaces was homogeneous in group B, irregular in C. Morphologically the lungs of group C were
DISCUSSION
The use of morphometric techniques allowed us to delineate an anatomic entity of lungs characterized by an exaggerated but homogeneous enlargement of airspaces without destruction (group B), distinct on the one hand from normal (group A), and on the other hand from emphysematous lungs (group C).
The estimation of the enlargement of the airspaces was achieved on the basis of the mean linear intercept, Lm, the uniformity of the airspaces by comparing Lm in upper and lower lobes and by computing
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