Chest
Original ResearchSleep MedicineUrine Concentrations of Cysteinyl Leukotrienes in Children With Obstructive Sleep-Disordered Breathing
Section snippets
Participants
Children referred to the sleep disorders laboratory for polysomnography due to symptoms of SDB were recruited. Children with a history of recurrent tonsillitis and without snoring participated as control subjects. Exclusion criteria for both patients and control subjects were cardiovascular, neuromuscular, or genetic disorders; acute symptoms or signs of asthma or respiratory tract infection (eg, bronchiolitis); symptoms or signs of other acute or chronic inflammatory disorders; eczema, and
Subjects' Characteristics and Polysomnography Findings
One hundred children were considered for participation in the study, and 8 were excluded due to acute symptoms of asthma (3), current use of antihistamines or montelukast (3), and history of eczema (2). Thus, a total of 92 subjects (43 female subjects; 46.7%) were recruited, and Table 1 summarizes their characteristics. Eighteen children were control subjects without snoring (mean age, 6.4 ± 2.5 years), 26 subjects had PS (mean age, 7 ± 2.6 years), 29 subjects had mild SDB (mean age, 5.1 ± 1.5
Discussion
CysLTs have been mainly studied for their role in asthma and allergic rhinitis.20, 21 However, recently published investigations have revealed increased CysLTs activity in the upper airway of children with SDB.2, 3, 4, 10 In the present report, urine levels of CysLTs were significantly associated with severity of SDB. In addition, CysLTs, tonsillar size, and BMI z score were significant predictors of OAHI.
Increased immunostaining for CysLTs receptors (type 1 CysLT receptor [LT1-R] and type 2
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This research was funded by the University of Thessaly Research Committee.
The authors have no conflicts of interest to disclose.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).