Chest
Original ResearchLung CancerThe Extent of Lung Parenchyma Resection Significantly Impacts Long-Term Quality of Life in Patients With Non-Small Cell Lung Cancer
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Patient Populations and Surgical Procedure
The study population included 159 consecutive patients who were treated for NSCLC at the Department of General and Thoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, between January 1998 and December 2004. Informed consent was obtained from each patient, and the study protocol was approved by the local ethics committee. QOL, clinical outcome, and survival were assessed before and after surgery. The overall number of surgical resections was performed by four specialized
Results
Descriptions of the patients and procedures are shown in Table 1. Of the 159 patients included in the study, 131 underwent lobectomy or bilobectomy, and 28 underwent pneumonectomy. The procedures were performed to treat squamous cell carcinoma in 75 patients, adenocarcinoma in 65 patients, large cell carcinoma in 15 patients, and other malignancies in 4 patients. Postoperative complications are listed in Table 2. The patient response rate (following distribution of the QOL questionnaire) is
Discussion
Surgery remains the treatment of choice for early stage NSCLC. Secondary to morbidity and mortality, analysis of QOL is an important measure of the outcome of surgical interventions for malignant disease.9 In a review of previous QOL-related studies, Montazeri et al10 concluded that the use of a specific lung cancer questionnaire (the EORTC QLQ-LC13) in conjunction with a core questionnaire (the EORTC QLQ-C30) most accurately reflected the QOL of patients with lung cancer.
This prospective study
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SABR for Early Non-Small Cell Lung Cancer: Changes in Pulmonary Function, Dyspnea, and Quality of Life
2023, International Journal of Radiation Oncology Biology PhysicsQuality of Life in Octogenarians After Lung Resection Compared to Younger Patients
2022, Clinical Lung CancerCitation Excerpt :It is now widely agreed that age alone should no longer be a contraindication to surgical treatment of lung cancer, however consideration of limited resections and avoidance of pneumonectomy is encouraged.4-10,14-16,32 Furthermore, there is increasing interest in the surgical management of the octogenarian4-9,13,14; and research on QOL is also becoming more widespread.17-20,22,23 However, literature focused on postoperative QOL in elderly patients with lung cancer treated surgically, especially octogenarians, remains minimal.
Chronic Pain After Lung Resection: Risk Factors, Neuropathic Pain, and Quality of Life
2020, Journal of Pain and Symptom ManagementPerioperative course and quality of life in a prospective randomized multicenter phase III trial, comparing standard lobectomy versus anatomical segmentectomy in patients with non-small cell lung cancer up to 2 cm, stage IA (7th edition of TNM staging system)
2019, Lung CancerCitation Excerpt :QoL has been studied comparing the surgical approach [11–13,30] or analyzed the impact of resected lung volume [15–17,31]. Furthermore, some studies have assessed the duration of recovery of QoL post-surgery in disease-free patients [14,32,33]. The most consistent decline in the QoL was documented in the first 6 weeks after surgery.
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Dr. Schulte and Dr. Schniewind contributed equally to this work.
The authors have no conflicts of interest to disclose.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).