Chest
Original ResearchControl of BreathingExercise Oscillatory Ventilation: Instability of Breathing Control Associated With Advanced Heart Failure
Section snippets
Materials and Methods
The study was approved by the Mayo Clinic College of Medicine Institutional Review Board. All subjects provided informed consent.
Subject Characteristics
The frequency of EOV for all ambulatory patients without ischemia who had been referred for cardiopulmonary exercise testing was 47 of 1,340 (3.5%) compared to 45 of 646 (7.0%) for those with a referral diagnosis of HF (p < 0.001). The study group (n = 47) and control group (n = 47) were not different with regard to LVEF, body mass index, gender, or therapy with β-blockers, digitalis, and diuretics. On univariate analysis, characteristics that discriminated EOV subjects from control subjects
Discussion
A unique and noteworthy finding of this study was that a substantial proportion of EOV subjects (41%) had an LVEF of ≥ 0.40. Indeed, on average, EOV subjects had normal stroke volume and cardiac index that were not different from control subjects, indicating that severe LV systolic dysfunction is not a prerequisite for EOV. Additional novel observations were that EOV subjects had larger left atrial volume, findings that are consistent with higher estimated left atrial, pulmonary venous and
ACKNOWLEDGMENT
We thank Kathy O'Malley and Angela Heydmann for assistance in data management, and Michelle Small for manuscript preparation.
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This study was supported by the Mayo Foundation, and National Heart Lung and Blood Institute grants HL71478, HL71478S1, HL-65176, HL-70302, and HL-73211.
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.