Issues in Pulmonary NursingRelationship between different indices of exercise capacity and clinical measures in patients with chronic obstructive pulmonary disease*,**
Section snippets
Patients and pulmonary function tests
We recruited 41 consecutive male patients with stable COPD (age, 47 to 80 years; FEV1, 0.32 to 1.94 L) as defined by the American Thoracic Society.8 We then compared the 3 exercise tests in evaluation of the effects of oxitropium bromide on exercise performance in a randomized, double-blind, placebo-controlled, crossover way, as previously reported.9 In this study, we reviewed the data on these patients and selected complete cases in which we could investigate the relationship between exercise
Results
We studied a total of 36 male patients with COPD with complete data sets who had a wide range of percentages of predicted FEV1 values (%FEV1, 13.6% to 75.4%). Among these patients, %FEV1 values were below 35% in 16 patients, 35% to 50% in 10 patients, and 50% to 79% in 10 patients, according to the categorization based on %FEV1 proposed by the American Thoracic Society.8 The FEV1/vital capacity ratios were 39.2% ± 11.1%. The results of pulmonary function tests, exercise tests, the clinical
Discussion
We found that exercise capacity on the walking test, progressive cycle ergometry, and the cycle endurance test all had moderately significant correlations with airflow limitation, hyperinflation, diffusing capacity, dyspnea, and HRQoL of patients with COPD. However, the interrelationships between exercise capacity evaluated with the different methods were moderate, and we found some differences among them. Noseda et al7 compared these commonly used exercise tests from the point of
Conclusion
Exercise capacity on 3 different exercise tests had statistically significant correlations with airflow limitation, hyperinflation, diffusing capacity, dyspnea during the activities of daily living, and HRQoL in patients with COPD. Although the 3 exercise tests are believed to evaluate approximately the same aspects, some differences were observed. Exercise capacity is an important outcome measure in patients with COPD, and acknowledgment of the different aspects evaluated is also important in
Acknowledgements
We thank Ms Kazuyo Haruna and Ms Yumiko Tomita for conducting the pulmonary function tests. We also thank Paul W. Jones, MD, (St George's Hospital Medical School, London, United Kingdom) for the use of the Japanese version of the St George's Respiratory Questionnaire.
References (28)
Mechanisms and measures of exercise intolerance in chronic obstructive pulmonary disease
Clin Chest Med
(2000)- et al.
How should we measure function in patients with chronic heart and lung disease?
J Chron Dis
(1985) Chronic obstructive pulmonary disease: the importance of exercise
Can Respir J
(2000)- et al.
Variables related to increased mortality following out-patient pulmonary rehabilitation
Eur Respir J
(1996) The importance of spirometry in COPD and asthma: effect on approach to management
Chest
(2000)- et al.
Relation of lung function, maximal inspiratory pressure, dyspnoea, and quality of life with exercise capacity in patients with chronic obstructive pulmonary disease
Thorax
(1994) - et al.
Lung function, maximum and submaximum exercise testing in COPD patients: reproducibility over a long interval
Lung
(1989) - et al.
Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease
Am J Respir Crit Care Med
(1995) - et al.
The effects of oxitropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease: a comparison of three different exercise tests
Am J Respir Crit Care Med
(2000) The predicted values of pulmonary function testing in Japanese
Jpn J Thoracic Dis
(1993)
Dyspnoea, disability, and distance walked: comparison of estimates of exercise performance in respiratory disease
Br Med J
Psychophysical basis of perceived exertion
Med Sci Sports Exerc
The Hospital Anxiety and Depression Scale
Acta Psychiatr Scand
A self-complete measure of health status for chronic airflow limitation: the St. George's Respiratory Questionnaire
Am Rev Respir Dis
Cited by (44)
Determinants of functional, peak and endurance exercise capacity in people with chronic obstructive pulmonary disease
2018, Respiratory MedicineCitation Excerpt :This concurs with previous research which suggested that subjective variables are more strongly related to walking tests than to cycle tests [5]. Only one study has previously examined the determinants of all three different constructs of exercise capacity, however measures of cardiac function were not included and the sample size was very small (n = 36) [40]. This is the first large study to comprehensively examine a large number of important clinical characteristics of people with COPD and their association with functional, peak and endurance exercise capacity.
Determinants of exercise capacity in obese and non-obese COPD patients
2014, Respiratory MedicineCitation Excerpt :The six-minute walking test (6MWT) [8] and the incremental cardiopulmonary exercise (CPET) [9] are well accepted tests to evaluate exercise capacity in COPD (10–12). Yet, neither peak oxygen uptake (VO2 peak) determined during CPET [10–12] or the six-minute walking distance (6MWD) can be adequately predicted from the degree of airflow limitation [13–15] as an isolated factor, indicating that factors other than lung function impairment also modulate exercise capacity in COPD. Obesity [16] is often associated with COPD and it has the potential to contribute to exercise limitation [17,18], but its individual contribution to impaired aerobic capacity in these patients is unclear [18–21].
Lower limb activity and its determinants in COPD
2008, ThoraxOxidative Stress and Quolity of Life in Severe Copd in Stable Phase
2023, Research Square
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Supported in part by the Smoking Research Foundation of Japan.
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Reprint requests: Toru Oga, MD, Respiratory Division, Kyoto-Katsura Hospital, 17 Yamadahirao, Nishikyo-ku, Kyoto, 615-8256, Japan.