Food and Drug Reactions and AnaphylaxisBiochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib☆,☆☆,★
Section snippets
Subjects
Thirty-three subjects (Table I) with asthma and aspirin intolerance were recruited from the University Hospitals in Stockholm (n = 12), Krakow (n = 11), and Nashville (n = 10).
Subject no. Age (y) Sex FEV1 (L) FEV1 (% predicted) Regular drug treatment (explanations below) 1 53 F 2.16 84.7 ICS, LAB, LTRA, SAB 2 30 M 3.99 97.8 SAB 3 69 F 1.53 85.0 ICS, LAB, SAB 4 29 F 3.01 100.3 ICS, NCS, LAB, LTRA, SAB 5 36 F 2.46 89.8 SAB 6 47 F 2.18 82.0 ICS, NCS, LAB, LTRA, SAB 7 56 F 2.15 88.1 ICS, SAB 8 46 F 2.03 75.5 ICS, LAB, LTRA, SAB
Airway responses
There were no significant bronchoconstrictor responses after placebo or active drug administration during the double-blind phase (Fig 2, A ).
Discussion
In this study of 33 patients with asthma and documented aspirin intolerance, all subjects tolerated the selective COX-2 inhibitor celecoxib. Although celecoxib was administered in increasing doses up to twice the normal clinical dose, there were no untoward reactions observed from the lower or upper airways, the eyes, the skin, the gastrointestinal system, or any other organ system. Neither was there a change in urinary LTE4 after the exposure to celecoxib. Thus clinical symptoms, pulmonary
Acknowledgements
We thank Margareta Andersson, Heléne Blomqvist, Margitha Dahl, Ingrid Delin, Gunnel DeForest, Christina Larsson, Brendie Keane, and Lee Morgan for expert technical assistance.
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Cited by (0)
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Drs Gyllfors and Bochenek contributed equally.
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Supported by an operating grant from Pharmacia Corp and infrastructure research support from The Swedish Heart Lung Foundation, The Swedish Medical Research Council (project 71X-9071), the Foundation for Health Care Sciences and Allergy Research, and National Institutes of Health grant GM15431.
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Reprint requests: Sven-Erik Dahlén, MD, PhD, Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, SE-171 77, Stockholm, Sweden.