Abstract
THE majority of peripheral T cells express a heterodimeric, α/β T-cell receptor, which recognizes specific antigenic peptides bound to self major histocompatibility complex (MHC) molecules, and either the CD4 or CD8 surface markers. An additional subset of T cells1,2, whose physiological function is unknown, express a distinct CD3-associated receptor composed of γ and δ chains1. This subset includes cells lacking both CD4 and CD8 surface markers, which may be involved in autoimmunity3–6. The recognition specificity of the γ/δ receptor is not well characterized and has been defined in only one case to date, a murine cell line which shows MHC-linked specificity7. In this report, we describe the isolation of CD4- CD8-, γ/δ TCR bearing T cell clones from the synovial fluid of a rheumatoid arthritis patient. These T cell clones respond specifically to mycobacterial antigens without MHC restriction.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Brenner, M. B. et al. Nature 322, 145–149 (1986).
Lanier, L. & Weiss, A. Nature 324, 268–270 (1986).
Morse, H. C. et al. J. Immun. 129, 2612–2615 (1982).
Hashimoto, Y., Maxam, A. M. & Greene, M. I. Proc. Natn. Acad. Sci. U.S.A. 83, 7865–7869 (1986).
Datta, S. K., Patel, H. & Berry, D. J. exp. Med. 165, 1252–1268 (1987).
Morisett, J. et al. Eur. J. Immun. 18, 387–394 (1988).
Matis, L. A., Cron, R. & Bluestone, J. A. Nature 330, 262–264 (1987).
Abrahamsen, T. G., Froland, S. S. & Natvig, J. B. Scand. J. Immun. 7, 81–90 (1978).
Lotz, M. et al. J. clin. Invest. 78, 713–721 (1986).
Holoshitz, J. et al. Lancet II, 305–309 (1986).
Ottenhoff, T. H. M. et al. Lancet II, 310–313 (1986).
Stansy, P. New Engl. J. Med. 298, 869–871 (1978).
Spits, H. et al. J. Immun. 135, 1922–1928 (1985).
Jitsukawa, S., Faure, F., Lipinski, M., Triebel, F. & Hercend, T. J. exp. Med. 166, 1192–1197 (1987).
Kung, P. Nature 330, 501–502 (1987).
Rivas, A., Koide, J., Cleary, M. L. & Engleman, E. G. J. Immun. 142, 1840–1846 (1989).
Kitamura, K. et al. J. Immun. 139, 3251–3259 (1987).
Ferrini, S. et al. J. exp. Med. 166, 277–282 (1987).
Moingeon, P. et al. Nature 323, 638–640 (1986).
DeBruyn, J. et al. Infect. Immun. 55, 245–252 (1987).
Ottenhoff, T. H. M. et al. Nature 329, 66–68 (1986).
Band, H. et al. Science 238, 682–684 (1987).
Koning, F. et al. J. exp. Med. 166, 595–600 (1987).
Loh, E. Y. et al. Nature 330, 569–572 (1987).
Lew, A. M. et al. J. Immun. 138, 807–814 (1987).
Ottenhoff, T. H. M., Elferink, D. G., Termijtelan, A., Koning, F. & de Vries, R. R. P. Human Immun. 13, 117–123 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Holoshttz, J., Strober, S., Koning, F. et al. Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339, 226–229 (1989). https://doi.org/10.1038/339226a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/339226a0
This article is cited by
-
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Signal Transduction and Targeted Therapy (2023)
-
Immune dysregulation and pathogenic pathways mediated by common infections in rheumatoid arthritis
Folia Microbiologica (2023)
-
Clinical, Diagnostic and Prognostic Characteristics of Primary Cutaneous Gamma Delta T-cell Lymphomas
Clinical Hematology International (2022)
-
Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions
Cellular & Molecular Immunology (2020)
-
γδ-T cells: an unpolished sword in human anti-infection immunity
Cellular & Molecular Immunology (2013)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.