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Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing

Nature volume 312, pages 729–734 (1984)Cite this article

Abstract

A novel mammalian neuropeptide, the tachykinin substance K, is specified by a discrete genomic segment. Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene. Relative amounts of the mRNAs vary in different tissues, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner.

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Authors and Affiliations

  1. Institute for Immunology, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Hiroyuki Nawa, Hirokazu Kotani & Shigetada Nakanishi

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  1. Hiroyuki Nawa
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  2. Hirokazu Kotani
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  3. Shigetada Nakanishi
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Nawa, H., Kotani, H. & Nakanishi, S. Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing. Nature 312, 729–734 (1984). https://doi.org/10.1038/312729a0

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