Abstract
Studies of somatic cell hybrids have assigned the gene cluster for human immunoglobulin heavy chains μ, γ and α to chromosome 14 (ref. 1). The locus for Gm (GM), a genetic marker on the γ heavy chain, has been shown to be linked to PI, the locus for α1-antitrypsin/α1-protease inhibitor (α1AT), a major protease inhibitor in human serum2,3. This assignment has now been confirmed by studies of somatic cell hybrids which have assigned α1AT also to chromosome 14 (refs 4,23). From studies of two families having abnormalities involving the long arm of chromosome 14, we have localized GM to the terminal portion of 14q at band q32.3 and PI to a more proximal position, between q24.3 and q32.1. The immunoglobulin genes are within a chromosome region noted for its high frequency of breaks associated with chromosome rearrangement, which occur both spontaneously in cultured lymphocytes and in certain malignancies.
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Cox, D., Markovic, V. & Teshima, I. Genes for immunoglobulin heavy chains and for α1-antitrypsin are localized to specific regions of chromosome 14q. Nature 297, 428–430 (1982). https://doi.org/10.1038/297428a0
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DOI: https://doi.org/10.1038/297428a0
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