Abstract
The central neural regulation of feeding and autonomic outflow are not always parallel in energy homeostasis, and a dysfunction of autonomic neural circuits rather than feeding behavior could be a primary causative factor in obesity.
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References
Friedman, J.M. & Halaas, J.L. Leptin and the regulation of body weight in mammals. Nature 395, 763– 770 (1998).
Elimquist, J.K., Maratos-Flier, E., Saper C.B. & Flier, J.S. Unraveling the central nervous system pathways underlying responses to leptin. Nature Neurosci. 1, 445– 450 (1998).
Bray, G.A. & York, D.A. Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis. Physiol. Rev. 59, 791–809 (1979).
Shimazu, T. Neural regulation of hepatic glucose metabolism in mammals. Diabetes Metab. Rev. 3, 185–206 (1987).
Collins, S. et al. Role of leptin in fat regulation. Nature 380, 677 (1996).
Mantzoros, C.S., et al. Activation of β3 adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 45, 909– 914 (1996).
Curzon, G., Gibson, E.L. & Qluyomi, A.Q. Appetite suppression by commonly used drugs depends on 5-HT receptors but not 5-HT availability. Trends Pharmacol. Sci. 18, 21–25 (1997).
Nonogaki, K., Strack, A.M., Dallman, M.F. & Tecott, L.H. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2c receptor gene. Nature Med. 4, 1152–1156 (1998).
Nonogaki, K. & Iguchi, A. Stress, acute hyperglycemia and hyperlipidemia: role of autonomic nervous system and cytokines. Trends Endocr. Metab. 8, 192–197 (1997).
Havel, P.J. et al. Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin. Am. J. Physiol. 274, R1482–R1491 (1998).
Malabu, U.H. et al. Effects of chronic vanadate administration in the STZ-induced diabetic rat. Diabetes 43, 9– 15. (1994).
Sainsbury, A. et al. Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinemia. Diabetologia 40, 1269– 1277 (1997).
Saladin, R. et al. Transient increase in obese gene expression after food intake or insulin administration. Nature 377, 527–529 (1995).
Biden, G., Chen, X., Kolaczynski, J.W. & Polansky, M. Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J. Clin. Invest. 100, 1107– 1113 (1997).
Barr, V.A. et al. Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology 138, 4463–4472 (1997).
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Nonogaki, K. Obesity: Autonomic circuits versus feeding. Nat Med 5, 742–743 (1999). https://doi.org/10.1038/10464
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DOI: https://doi.org/10.1038/10464
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