Skip to main content
SpringerLink
Log in

Gene-Gene Interactions between Glutathione-S Transferase M1 and Matrix Metalloproteinase 9 in the Formation of Hereditary Predisposition to Chronic Obstructive Pulmonary Disease

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The incidence of allele variants of glutathione-S transferase M1 xenobiotic detoxification gene and matrix metalloproteinase 9 gene was analyzed in patients with chronic obstructive pulmonary disease. A strict gene-gene interaction between these two genes in the formation of hereditary predisposition to this disease was first demonstrated. The combination of glutathione-S transferase M1 genotype 0/0 and matrix metalloproteinase 9 mutant allele (-15621) is a risk factor for chronic obstructive pulmonary disease (OR-7.7).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. H. Baranova, J. Perriot, E. Albuisson, et al., Hum. Genet., 99, 822–826 (1997).

    Google Scholar 

  2. L. Joos, P. D. Pare, and A. J. Sandford, Swiss Med. Wkly, 132, Nos. 3-4, 27–37 (2002).

    Google Scholar 

  3. . H. Koyama and D. M. Geddes, Thorax, 53, Suppl. 2, S10–S14 (1998).

    Google Scholar 

  4. N. Pearce, Int. J. Epidemiol., 22, No. 6, 1189–1192 (1993).

    Google Scholar 

  5. A. J. Sandford and E. K. Silverman, Thorax, 57, No. 8, 736–741 (2002).

    Google Scholar 

  6. R. M. Senior, G. L. Griffin, C. J. Fliszar, et al., J. Biol. Chem., 266, 7870–7875 (1991).

    Google Scholar 

  7. The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 to 2020, Eds. C. J. L. Murray and A. D. Lopez, Cambridge (1996).

  8. B. Zhang, S. Ye, S.-M. Herrmann, et al., Circulation, 99, 1788–1794 (1999).

    Google Scholar 

  9. S. Zhong, A. H. Wyllie, D. Barnes, et al., Carcinogenesis, 14, No. 9, 1821–1824 (1993).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Genetic Technologies, Research Center, Institute of Pulmonology, St. Petersburg I. P. Pavlov State Medical University, St. Petersburg

    E. D. Yanchina, T. V. Ivchik, E. I. Shvarts, A. N. Kokosov & N. E. Khodzhayantz

  2. Laboratory of Human Molecular Genetics, Institute of Nuclear Physics, Russian Academy of Sciences, St. Petersburg

    E. D. Yanchina, T. V. Ivchik, E. I. Shvarts, A. N. Kokosov & N. E. Khodzhayantz

Authors
  1. E. D. Yanchina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. V. Ivchik
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. I. Shvarts
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. N. Kokosov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. E. Khodzhayantz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yanchina, E.D., Ivchik, T.V., Shvarts, E.I. et al. Gene-Gene Interactions between Glutathione-S Transferase M1 and Matrix Metalloproteinase 9 in the Formation of Hereditary Predisposition to Chronic Obstructive Pulmonary Disease. Bulletin of Experimental Biology and Medicine 137, 64–66 (2004). https://doi.org/10.1023/B:BEBM.0000024389.16247.0a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:BEBM.0000024389.16247.0a

Search

Navigation