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Ambient air pollution exposure and cancer

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Abstract

Epidemiologic evidence on the relation between ambient air pollution exposure and cancer is reviewed. The well-documented urban/rural difference in lung cancer incidence and the detection of known carcinogens in the atmosphere gave rise to the hypothesis that long-term exposure to air pollution may have an effect on lung cancer risk. However, problems inherent in assessing adequately the exposure of interest led to considerable difficulties in evaluating this effect. Routinely measured air pollutants do not include, as a rule, established carcinogens, and air pollution measurements usually come from fixed-site monitors, making it difficult to estimate individual exposures, especially long-term. The nature of the exposure and associated measurement problems made ecologic comparisons a natural way to approach the study of air pollution effects on lung cancer risk. The descriptive/ecologic studies which have been undertaken after 1950 often had problems with inadequate control of confounding, but, on the whole, provided evidence compatible with the hypothesis that urban and industrial air pollution may have an effect on lung cancer risk. The results of several case-control and cohort studies are described in the present review with emphasis on the exposure metric used. These studies, which control for important potential confounders, suggest that urban air pollution may be a risk factor for lung cancer, with estimated relative risks in the order of up to about 1.5 in most situations.

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References

  1. Ware JH, Thibodeau LA, Speizer FE, Colome S, Ferris BG. Assessment of the health effects of atmospheric sulphur oxides and particulate matter. Evidence from observational studies. Environ Health Perspect 1981; 41: 255–76.

    Google Scholar 

  2. Shy CM, Goldsmith JR, Hackney JD, Lebowitz MD, Manzel DB. Health effects of air pollution. Am Thoracic Soc News 1978; 4: 22–63.

    Google Scholar 

  3. Muir C, Waterhouse J, Mack T, Powell J, Whelan S. eds. Cancer Incidence in Five Continents. Lyon, France: International Agency for Research on Cancer, 1987; IARC Sci. Pub. No. 88.

    Google Scholar 

  4. Lambert PM, Reid DD. Smoking, air pollution and bron-chitis in Britain. Lancet 1970; i: 853–7.

    Google Scholar 

  5. World Health Organization. Air Quality Guidelines for Europe. Copenhagen, Denmark: WHO, 1987; WHO Regional Publications, European Series, No 23.

    Google Scholar 

  6. Pershagen G, Simonato L. Epidemiological evidence on outdoor air pollution and cancer. In: Tomatis L, ed. Air Pollution and Human Cancer. Berlin, Germany: Springer-Verlag, 1990.

    Google Scholar 

  7. Speizer FE, Samet JM. Air pollution and lung cancer. In: Samet J M. Epidemiology of Lung Cancer. New York, NY (USA): Marcel Dekker Inc, 1994.

    Google Scholar 

  8. Tomatis L, ed. Cancer: Causes, Occurrence and Control. Lyon, France: International Agency for Research on Cancer, 1990; IARC Sci. Pub. No. 100: 229–33.

    Google Scholar 

  9. Cohen AJ, Pope AC III. Lung cancer and air pollution. Environ Health Perspect 1995; 103(Suppl 8): 219–24.

    Google Scholar 

  10. Samet JM, Cohen AJ. Air pollution and lung cancer. In: Swift DL, ed. Air Pollutants and the Respiratory Tract. New York, NY (USA): Marcel Dekker, (in press).

  11. Archer VE. Air pollution and fatal lung disease in three Utah countries. Arch Environ Health 1990; 45: 325–34.

    Google Scholar 

  12. Tango T. Effect of air pollution on lung cancer: a Poisson regression model based on vital statistics. Environ Health Perspect 1994; 102(Suppl 8): 41–5.

    Google Scholar 

  13. Rothman K. Modern Epidemiology. Boston, MA (USA): Little, Brown and Co., 1986.

    Google Scholar 

  14. Stocks P, Campbell JM. Lung cancer death rates among non-smokers and pipe and cigarette smokers. Br Med J 1955; 2: 923–9.

    Google Scholar 

  15. Haenszel W, Loveland DB, Sirken MG. Lung cancer mortality as related to residence and smoking history: I White males. JNCI 1962; 28: 947–1001.

    Google Scholar 

  16. Haenszel W, Taeuber KE. Lung cancer mortality as related to residence and smoking history: II White females. JNCI 1964; 32: 803–38.

    Google Scholar 

  17. Hitosugi M. Epidemiological study of lung cancer with special reference to the effect of air pollution and smoking habit. Bull Inst Public Health 1968; 17: 236–55.

    Google Scholar 

  18. Dean G. Lung cancer and bronchitis in Northern Ireland 1960–2. Br Med J 1966; 1: 1506-14.

    Google Scholar 

  19. Dean G, Lee PN, Todd GF, Wicken AJ. Report on a second retrospective mortality study in Northeast England. Parts 1 and 2. London, UK: Tobacco Research Council, 1977–78.

  20. Pike MC, Jing JS, Rosario IP, Henderson BE, Menck HR. Occupation: 'Explanation' of an apparent air pollution related localized excess of lung cancer in Los Angeles County. In Breslow N, Whitemore A, eds. Energy and Health. Philadelphia, PA (USA): SIAM, 1979: 3–16.

    Google Scholar 

  21. Vena JE. Air pollution as a risk factor in lung cancer. Am J Epidemiol 1982; 116: 42–56.

    Google Scholar 

  22. Samet JM, Humble CG, Skipper BE, Pathak DR. History of residence and lung cancer risk in New Mexico. Am J Epidemiol 1987; 125: 800–11.

    Google Scholar 

  23. Xu ZY, Blot WJ, Xiao HP,et al. Smoking, air pollution and the high rates of lung cancer in Shenyang, China. JNCI 1989; 81: 1800–6.

    Google Scholar 

  24. Jedrychowski W, Becher H, Wahrendorf J, Basa-Cierpialek Z. Case-control study of lung cancer with special reference to the effect of air pollution in Poland. J Epidemiol Commun Health 1990; 44: 114–20.

    Google Scholar 

  25. Katsouyanni K, Trichopoulos D, Kalandidi A, Tomos P, Riboli E. A case-control study of air pollution and tobacco smoking in lung cancer among women in Athens. Prev Med 1991; 20: 271–8.

    Google Scholar 

  26. Holowathy EJ, Risch HA, Miller AB, Burch JD. Lung cancer in women in the Niagara Region Ontario: a case-control study. Can J Public Health 1991; 82: 304–9.

    Google Scholar 

  27. Jockel KH, Ahrens W, Wichmann HE,et al. Occupational and environmental hazards associated with lung cancer. Int J Epidemiol 1992; 21: 202–13.

    Google Scholar 

  28. Barbone F, Bovenzi M, Cavallieri F, Stanta G. Air pollution and lung cancer in Trieste, Italy. Am J Epidemiol 1995; 141: 1161–9.

    Google Scholar 

  29. Drescher K, Timm J. The design of case-control studies: the effect of confounding on sample size requirements. Stat Med 1990; 9: 765–76.

    Google Scholar 

  30. Hammond EC, Horn D. Smoking and death rates-report on forty-four months of follow-up of 187783 men. JAMA 1958; 166: 1294–308.

    Google Scholar 

  31. Buell P, Dunn JE, Breslow L. Cancer of the lung and Los Angeles type air pollution. Cancer 1967; 20: 2139–47.

    Google Scholar 

  32. Hammond EC. Smoking habits and air pollution in relation to lung cancer. In: Lee DHK, ed. Environmental Factors in Respiratory Disease. New York, NY (USA): Academic Press, 1972: 177–98.

    Google Scholar 

  33. Cederlof R, Friberg L, Hrubec Z, Lorich U. The relation-ship of smoking and some social covariables to mortality and cancer morbidity. Stockholm, Sweden: Department of Environmental Hygiene, Karolinska Institute, 1975.

    Google Scholar 

  34. Doll R, Peto R. The causes of cancer: Quantitative estimates of avoidable risks of cancer in the U.S. today. JNCI 1981; 66: 1191–308.

    Google Scholar 

  35. Tenkanen L, Teppo L. Migration, marital status and smoking as risk determinants of cancer. Scand J Soc Med 1987; 15: 67–72.

    Google Scholar 

  36. Mills PK, Abbey D, Beeson WL, Petersen F. Ambient air pollution and cancer in California. Seventh-day adventists. Arch Environ Health 1991; 46: 271–80.

    Google Scholar 

  37. Dockery DW, Pope CA III, Xu X,et al. An association between air pollution and mortality in six U.S. cities. New Eng J Med 1993; 329: 1753–9.

    Google Scholar 

  38. Pope CA III, Thun MJ, Namboodiri MM,et al. Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Respir Crit Care Med 1995; 151: 669–74.

    Google Scholar 

  39. Ackermann-Liebrich U, Viegi G, Nolan C, eds. Time-activity patterns in exposure assessment. Luxembourg: European Commission, DGXII; Air Pollution Epidemiology Report Series, Report Number 6, 1995.

    Google Scholar 

  40. Jantunen MJ, Hanninen O, Saarela K,et al. Air pollution exposure distributions of adult urban populations in Europe: design of the 'EXPOLIS' study. The 7th International Conference on Indoor Air Quality and Climate, July, 1996, Nagoya, Japan. Proceedings, Vol 1: 1125–9.

    Google Scholar 

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Katsouyanni, K., Pershagen, G. Ambient air pollution exposure and cancer. Cancer Causes Control 8, 284–291 (1997). https://doi.org/10.1023/A:1018492818416

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