Elsevier

Respiratory Medicine

Volume 108, Issue 4, April 2014, Pages 654-659
Respiratory Medicine

Risk factors for 1-year relapse of pulmonary tuberculosis treated with a 6-month daily regimen

https://doi.org/10.1016/j.rmed.2014.01.010Get rights and content
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Summary

Background

We aimed to identify the 1-year relapse rate and risk factors for patients with pulmonary tuberculosis (TB) treated with a 6-month daily regimen.

Methods

A total of 317 patients with pan-susceptible pulmonary TB who completed a 6-month daily course of treatment [2HRZ(E)/4HR(E)] were retrospectively analyzed.

Results

The mean age was 50.0 ± 16.8 years and men were predominant (61.2%). All of 137 adults tested for HIV were negative. Six (1.9%) cases relapsed within one year. Relapse rate was higher in patients with a positive culture after 2 months of treatment (10.0%, p = 0.049) and in patients with both a positive culture after 2 months of treatment and cavitation on initial chest radiograph (18.2%, p = 0.015), whereas relapse rate in patients with cavitation alone was comparable to that of the total population (2.7%). Among various risk factors known to increase risk of relapse, the combined variable of cavitation and positive culture at 2 months (OR = 15.56, 95% CI 2.56–98.71, p = 0.003) was only associated with increased relapse rate in a multivariate analysis.

Conclusions

Even with a 6-month daily treatment regimen throughout the intensive and continuation phases, the relapse rate was unacceptably high in patients with both a positive culture at 2 months of treatment and cavitation on baseline chest radiography. Intensification of treatment, such as an extension of treatment duration, should be considered in this category of patients.

Keywords

Pulmonary tuberculosis
2-Month culture conversion
Cavity
Relapse

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