Elsevier

Respiratory Medicine

Volume 99, Issue 8, August 2005, Pages 966-975
Respiratory Medicine

Community-acquired pneumonia by Legionella pneumophila serogroups 1–6 in Brazil

https://doi.org/10.1016/j.rmed.2005.02.008Get rights and content
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Summary

A prospective cohort study of adult patients hospitalized due to community-acquired pneumonia was carried out for 1 year in a Brazilian university general hospital to detect the incidence of community-acquired pneumonia by Legionella pneumophila serogroups 1–6. During a whole year, a total of 645 consecutive patients who were hospitalized due to a initial presumptive diagnosis of respiratory disease by ICD-10 (J00–J99), excluding upper respiratory diseases, were screened to detect the patients with community-acquired pneumonia. Fifty-nine consecutive patients hospitalized due to community-acquired pneumonia between July 19, 2000 and July 18, 2001, were included in the study. They had determinations of serum antibodies to L. pneumophila serogroups 1–6 by indirect immunofluorescence antibody test at the Infectious Diseases Laboratory of University of Louisville (KY, USA) and urinary antigen tests for L. pneumophila serogroup 1. Three patients had community-acquired pneumonia by L. pneumophila serogroups 1–6, two patients being diagnosed by seroconversion and positive urinary antigen tests; the other had negative serologies but strongly positive urinary antigen test. The incidence of community-acquired pneumonia by L. pneumophila serogroups 1–6 in our hospital was 5.1%.

Keywords

Legionnaires’ disease
Community-acquired pneumonia
Legionella urinary antigen
Brazil

Abbreviations

CAP
community-acquired pneumonia
COPD
chronic obstructive pulmonary disease
BAL
bronchoalveolar lavage
HRCT
high resolution computed tomography
CT
computed tomography
WHO
world health organization
CDC
center for diseases control
ELISA
enzyme-linked immunoabsorvent assay

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Financial Support: Fundação de Auxílio à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) and Grupo de Pesquisa e Pós-Graduação (GPPG) of Hospital de Clínicas de Porto Alegre, Brazil.