Variation in childhood asthma among former preterm infants☆
Section snippets
Sample
Participants were derived from a sample of 404 children born prematurely enrolled in the Cleveland Children's Sleep and Health Study. This is a cohort of 907 children born between 1988 and 1993, assembled by stratified sampling of preterm and term births at three area hospitals to achieve a sample of approximately 50% preterm and 35% African American children.21 Preterm children had been enrolled by identifying children born at ≤36 weeks' gestational age from the neonatal intensive care unit
Results
A total of 251 (60%) of the 404 premature members of the cohort could be classified as either asthmatic (n = 97) or nonasthmatic (n = 154) by using the specified study definitions (12 not classified because of missing data, one because of a confounding congenital syndrome, 18 because of a history of asthma but no recent symptoms or medication use, and 118 because symptoms or medication use were reported without an asthma diagnosis). There were no significant differences in the distribution of birth
Discussion
In this community-based study of former preterm children, we have identified several demographic and host risk factors associated with asthma prevalence at ages 8 to 11 years and have attempted to distinguish which perinatal risk factors most strongly predict asthma later in childhood. Our unadjusted analyses confirm previous reports that have identified African American ethnicity, male gender, maternal history of asthma, low birth weight, and CLD as significant risk factors for asthma among
References (40)
- et al.
Prematurity as a risk factor for asthma in preadolescent children
J Pediatr
(1993) - et al.
Health of very low birth weight children during their first eight years
J Pediatr
(1993) - et al.
Prevalence and risk factors for sleep-disordered breathing in 8 to 11 year-old children: association with race and prematurity
J Pediatr
(2003) - et al.
Growth and neurodevelopmental outcome of very low birth weight infants with intrauterine growth retardation: comparison with control subjects matched by birth weight and gestational age
J Pediatr
(1993) - et al.
Eight-year school performance and growth of preterm, small for gestational age infants: a comparative study with subjects matched for birth weight or for gestational age
J Pediatr
(1990) - et al.
Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1993 through December 1994
Am J Obstet Gynecol
(1998) - et al.
Neonatal characteristics as risk factors for preschool asthma
J Asthma
(1996) - et al.
Surveillance for Asthma—United States, 1980–999
Morb Mortal Wkly Rep CDC Surveill Summ
(2002) - et al.
Environmental exposure to endotoxin and its relation to asthma in school-age children
N Engl J Med
(2002) The coming-of-age of the hygiene hypothesis
Respir Res
(2001)
Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses
Respir Res
Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study
BMJ
Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease?
Clin Exp Allergy
Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children
Eur Respir J
Early antibiotic treatment and later asthma
Eur J Med Res
Asthma is associated with weight gain in females but not males, independent of physical activity
Am J Respir Crit Care Med
Association between obesity and asthma in 4-11 year old children in the UK
Thorax
Can the increase in body mass index explain the rising trend in asthma in children?
Thorax
Changing patterns of low birthweight and preterm birth in the United States, 1981-98
Paediatr Perinat Epidemiol
Respiratory symptoms in children of low birth weight
Arch Dis Child
Cited by (51)
Maternal and neonatal risk factors of asthma in children: Nationwide population based study
2023, Journal of Microbiology, Immunology and InfectionRodent models of respiratory control and respiratory system development—Clinical significance
2019, Respiratory Physiology and NeurobiologyBronchopulmonary dysplasia as a risk factor for asthma in school children and adolescents: A systematic review
2018, Allergologia et ImmunopathologiaCitation Excerpt :Examination of the references cited in the selected articles yielded an additional seven studies of which two were rejected. The final review was thus based on 17 studies13–29, which are summarised in Table 1. Overall, the selected studies included a total of 1402 patients with a diagnosis of BPD in a global population of 7433 PTIs with a gestational age of under 32 weeks and/or with a weight at birth of less than 1500 g, born in the period between 1977 and 2005.
A systematic review of early life factors which adversely affect subsequent lung function
2016, Paediatric Respiratory ReviewsCitation Excerpt :Four studies were included in our review. Three of the five risk factor combinations investigated showed a significant association with subsequent low lung function [18,29,30,37]. The longest duration of follow-up in those studies was 12 years.
Prematurity, atopy, and childhood asthma in Puerto Ricans
2014, Journal of Allergy and Clinical ImmunologyExploring Modifiable Risk Factors for Wheezing in African American Premature Infants
2011, JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing
- ☆
Supported by grants RO1 HL60957, K23 HL04426, RO1 NR02707, and M01 RR00080-39 from the National Institutes of Health.