EditorialsEarly morphologic changes in the lungs of asymptomatic infants and young children with cystic fibrosis
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Cystic fibrosis in the 21st century: what every radiologist should know
2022, Clinical ImagingCitation Excerpt :Chronic airway obstruction from thick mucus leads to chronic inflammation, bacterial colonization and chronic infection. Resultant bronchial wall thickening, and bronchiectasis are the most characteristic findings of CF-related lung disease.14 Allergic bronchopulmonary aspergillosis (ABPA) is a common comorbidity of CF.
Differences in the pattern of structural abnormalities on CT scan in patients with cystic fibrosis and pancreatic sufficiency or insufficiency
2013, ChestCitation Excerpt :Figure 1 illustrates HRCT scan changes with predominant involvement of the upper lobes in a 21-year-old male patient with PI (TBS, 117) compared with more widespread changes in a male patient of the same age with PS (TBS, 25). HRCT scan is known for its sensitivity in detecting early lung disease in CF, demonstration of structural changes prior to detection of clinical and spirometric abnormalities,16,30–32 assessment of disease progression10,20,33 with corresponding clinical severity,15 and prediction of exacerbation rates.34 The current study demonstrates that patients with PI who carry class I or II CFTR mutations have significantly more-severe structural lung disease as seen on HRCT scan than patients with PS who carry class IV or V CFTR mutations.
Invasive mechanical ventilation in cystic fibrosis: Influence in lung transplant
2009, Anales de PediatriaImaging of the Chest in Cystic Fibrosis
2007, Clinics in Chest MedicineLung clearance index and HRCT are complementary markers of lung abnormalities in young children with CF
2011, ThoraxCitation Excerpt :Both HRCT and LCI have been suggested as possible markers of early CF lung disease. Both measures have been shown to be abnormal in young children with CF who still have normal spirometry 2 11–13 17 37 38 to worsen with increasing age on cross sectional studies,11 15 17 37 and with time on longitudinal studies;14 39 40 and to improve with CF therapy.41 42 It is therefore very likely that both these measures can detect early CF lung disease.
Article long-term imaging follow-up in dipnech: Multicenter experience
2021, Journal of Clinical Medicine