Elsevier

The Journal of Pediatrics

Volume 144, Issue 2, February 2004, Pages 145-146
The Journal of Pediatrics

Editorials
Early morphologic changes in the lungs of asymptomatic infants and young children with cystic fibrosis

https://doi.org/10.1016/j.jpeds.2003.11.008Get rights and content

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    Figure 1 illustrates HRCT scan changes with predominant involvement of the upper lobes in a 21-year-old male patient with PI (TBS, 117) compared with more widespread changes in a male patient of the same age with PS (TBS, 25). HRCT scan is known for its sensitivity in detecting early lung disease in CF, demonstration of structural changes prior to detection of clinical and spirometric abnormalities,16,30–32 assessment of disease progression10,20,33 with corresponding clinical severity,15 and prediction of exacerbation rates.34 The current study demonstrates that patients with PI who carry class I or II CFTR mutations have significantly more-severe structural lung disease as seen on HRCT scan than patients with PS who carry class IV or V CFTR mutations.

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