Asthma and lower airway diseaseAlternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations
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Key words
Alternaria alternata
allergic airway disease
asthma exacerbation
protease
IL-33
Abbreviations used
AEBSF
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
ALT
Alternaria
BALF
BAL fluid
CAT
Cat dander
HDM
House dust mite
MCPT-1
Mast cell protease-1
MMP-9
Matrix metalloproteinase-9
PAP
Papain
PAR-2
Protease activated receptor 2
RAG
Ragweed
TRYP
Trypsin
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This work was supported by the Welcome Trust (grants 086718/Z/08/Z and 095707/Z/11/Z).
Conflicts of interest: R. J. Snelgrove, L. G. Gregory, S. Akthar, and G. A. Campbell have received research support from the Wellcome Trust. S. A. Walker has received research support from the MRC-Asthma UK Centre in Allergic Mechanisms of Asthma. C. M. Lloyd has received research support from the Wellcome Trust, MedImmune Inc, Johnson & Johnson, and Respivert; and has received lecture fees from MedImmune Inc. Teresa Peiró was supported by research grants from Consellería de Educación, Generalitat Valenciana (BEFPI/2012/062 and ACIF/2010/114).
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These authors contributed equally to this work.
Copyright © 2014 The Authors. Published by Mosby, Inc.