Asthma and lower airway diseaseAsthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study
Section snippets
Multi-Ethnic Study of Atherosclerosis
The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter cohort study of subclinical cardiovascular disease in white, African American, Hispanic, and Asian subjects.22 Between 2000 and 2002, MESA recruited 6814 men and women 45 to 84 years of age from Forsyth County, North Carolina; New York City; Baltimore, Maryland; St Paul, Minnesota; Chicago, Illinois; and Los Angeles, California. Exclusion criteria were clinical cardiovascular disease, weight exceeding 136 kg (300 lb), pregnancy,
Results
The mean age of the 3371 participants was 65 years at the time of spirometry, 49% were male, and the race/ethic distribution was 34% white, 25% African American, 23% Hispanic, and 18% Chinese American. Fifty percent of the cohort never smoked cigarettes, 42% were former smokers, and 8% currently smoked.
Of the 3371 participants who met the inclusion criteria, 446 had asthma, and 2925 did not. Two hundred seventeen participants reported asthma onset in childhood and 102 as young adults.
Discussion
A history of asthma, particularly in childhood and young adulthood, was associated both with large decrements in lung function in later life and narrower segmental airways in this large, population-based cohort study. In addition, asthma onset in young adulthood was associated with increased %LAA.
The mean decrement in FEV1 in later life among participants with asthma with onset in childhood and young adulthood was greater than that among participants with a history of cigarette smoking (−365 mL
References (44)
The global burden of asthma
Chest
(2006)- et al.
The Melbourne Asthma Study: 1964-1999
J Allergy Clin Immunol
(2002) - et al.
COPD in never smokers: results from the population-based burden of obstructive lung disease study
Chest
(2011) - et al.
Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology
Chest
(2008) - et al.
High-resolution computed tomography scan and airway remodeling in children with severe asthma
J Allergy Clin Immunol
(2005) - et al.
Correlation between airflow limitation and airway dimensions assessed by multidetector CT in asthma
Respir Med
(2010) - et al.
Thin-section CT evidence of bronchial thickening in children with stable asthma: bronchoconstriction or airway remodeling?
Acad Radiol
(2001) - et al.
Cigarette smoking and airway wall thickness on CT scan in a multi-ethnic cohort: the MESA Lung Study
Respir Med
(2012) - et al.
Lung imaging in asthmatic patients: the picture is clearer
J Allergy Clin Immunol
(2011) - et al.
Role of small airways in asthma: investigation using high-resolution computed tomography
J Allergy Clin Immunol
(2006)
Chronic obstructive pulmonary disease in non-smokers
Lancet
Asthma as a risk factor for COPD in a longitudinal study
Chest
A 15-year follow-up study of ventilatory function in adults with asthma
N Engl J Med
Forced vital capacity paired with Framingham Risk Score for prediction of all-cause mortality
Eur Respir J
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
Am J Respir Crit Care Med
Asthma: from childhood to adulthood
Allergy
Airway inflammation is present during clinical remission of atopic asthma
Am J Respir Crit Care Med
Early life origins of chronic obstructive pulmonary disease
Thorax
Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning
Thorax
Airway structural alterations selectively associated with severe asthma
Am J Respir Crit Care Med
Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma
Eur Respir J
Cited by (22)
A Longitudinal Cohort Study of Aspirin Use and Progression of Emphysema-like Lung Characteristics on CT Imaging: The MESA Lung Study
2018, ChestCitation Excerpt :The progression of percent emphysema was modest, likely due to the general population sample. Given the mostly subclinical emphysema, the presence of baseline emphysema was previously confirmed by visual assessment in subsets.46,51 In this cohort, percent emphysema has also been associated with all-cause mortality,7 and a reduction of this magnitude may still be relevant in disease prevention.
The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA)
2017, AtherosclerosisCitation Excerpt :In a subset of participants enrolled in the MESA-Lung Sub-study (3965 of 4484 randomly sampled MESA participants), smoking was also evaluated by urinary cotinine using an immunoassay (Immulite 2000 Nicotine Metabolite Assay; Diagnostic Products Corp., Los Angeles, CA). The intra-assay coefficient of variation was 2.02% and undetectable values of cotinine were assigned to 7.07 ng/mL [22]. According to MESA protocol, participants were instructed not to smoke on the morning of the visit and urine was collected mid-to-late morning.
Interaction between allergic asthma and atherosclerosis
2016, Translational ResearchCharacteristics of phenotypes of elderly patients with asthma
2016, Allergology InternationalCitation Excerpt :This may be explained by the very mild to mild emphysema. Donohue et al. found that early-onset asthma contributed to greater %LAA in later life.21 Our results showed that 20% of asthma-predominant patients (who had no OAD) had very mild LAA.
Advances in pediatric asthma in 2013: Coordinating asthma care
2014, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Another emerging tool for assessing altered lung structure is computed tomography. Donohue et al60 observed that asthma examined with computed tomography in later adulthood after onset in childhood or young adulthood was associated with reduced lung function, narrower airways, and, among asthmatic patients who smoked, greater percentage of low attenuation area, possibly associated with air trapping, in later life. Cadman et al61 reported that magnetic resonance imaging with 3He detected more and larger regions of ventilation and a greater degree of restricted gas diffusion in children with asthma compared with values seen in children without asthma.
Supported by National Institutes of Health grants R01 HL077612, R01 HL075476, RC1 HL100543, and N01-HC95159-169. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Disclosure of potential conflict of interest: K. M. Donohue has received grants from the National Institutes of Health (NIH) and the Alpha One Foundation, has received travel support from the NIH, and is employed by Columbia University. E. A. Hoffman has received grants from the NIH and is a founder and shareholder of VIDA Diagnostics, a company commercializing lung image analysis software developed, in part, at the University of Iowa. H. Baumhauer has received grants and travel support from the University of Iowa. J. Guo has received grants from the NIH and is a shareholder in VIDA Diagnostics. D. R. Jacobs and P. Enright have received grants from the NIH. R. G. Barr has received grants from the NIH, has received royalties from UpToDate, and has received travel support from Boehringer Ingelheim. The rest of the authors declare that they have no relevant conflicts of interest.