Asthma and lower airway disease

SMART isn't

Last year’s “Advances in pediatric asthma” concluded with the following statement: “If we can close these [remaining] gaps through better communication, improvements in the health care system and new insights into treatment, we will move closer to better methods to intervene early in the course of the disease and induce clinical remission as quickly as possible in most children.” This year’s summary will focus on recent advances in pediatric asthma that take steps moving forward as reported in Journal of Allergy and Clinical Immunology publications in 2010. Some of these recent reports show us how to improve asthma management through steps to better understand the natural history of asthma, individualize asthma care, reduce asthma exacerbations, and manage inner-city asthma and some potential new ways to use available medications to improve asthma control. It is clear that we have made many significant gains in managing asthma in children, but we have a ways to go to prevent asthma exacerbations, alter the natural history of the disease, and reduce health disparities in asthma care. Perhaps new directions in personalized medicine and improved health care access and communication will help maintain steady progress in alleviating the burden of this disease in children, especially young children.

This summary reviews research published over the past year on asthma and through the prism of health care delivery and quality. Special attention is given to management, therapeutics, and the role of environmental exposures and their interactions with genetics. The discussion is framed around the 3 stages of translational research: from bench to first studies in human subjects, then to larger efficacy studies in well-defined patient populations, and finally into practice through effectiveness research in real-world settings.