Food, drug, insect sting allergy, and anaphylaxisEarly consumption of peanuts in infancy is associated with a low prevalence of peanut allergy
Section snippets
Questionnaires
Two validated questionnaires were used. Questionnaires recorded categorical answers only.
FAQ
The FAQs were distributed to 10,786 children in 24 schools (13 in the UK and 11 in Israel). Eight thousand eight hundred twenty-six were returned, resulting in an overall response rate of 81.8% (80.2% [4148/5171] in the UK and 83.2% [4672/5615] in Israel). Two hundred twenty-six FAQs were excluded from analysis (220 were outside the age range [ie, <4 or ≥19 years of age], 2 were duplicates, and 4 had an incorrect school code). Of the 8826 returned FAQs, 7880 were returned after initial sampling
Discussion
Using a questionnaire-based study of 8600 schoolchildren, we have shown that the prevalence of PA is 10-fold higher in Jewish children in the UK compared with that seen in Jewish children in Israel (1.85% and 0.17%, respectively). Furthermore, the prevalence of PA appears to be increasing in the UK, whereas in Israel it remains stable among all age groups. These differences cannot be explained by differences in age, sex, ancestry, atopy, or socioeconomic class. After adjustment for atopy, other
References (47)
- et al.
The impact of government advice to pregnant mothers regarding peanut avoidance on the prevalence of peanut allergy in United Kingdom children at school entry
J Allergy Clin Immunol
(2007) - et al.
Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study
J Allergy Clin Immunol
(2003) - et al.
The natural progression of peanut allergy: resolution and the possibility of recurrence
J Allergy Clin Immunol
(2003) - et al.
Fatalities due to anaphylactic reactions to foods
J Allergy Clin Immunol
(2001) - et al.
The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance
J Allergy Clin Immunol
(1995) Epidemiologic risks for food allergy
J Allergy Clin Immunol
(2008)- et al.
IgE food sensitization in infants with eczema attending a dermatology department
J Pediatr
(2007) - et al.
Distribution of peanut allergen in the environment
J Allergy Clin Immunol
(2004) - et al.
Peanut allergen exposure through saliva: assessment and interventions to reduce exposure
J Allergy Clin Immunol
(2006) - et al.
Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy
J Allergy Clin Immunol
(2004)
Nickel allergy in adolescents in relation to orthodontic treatment and piercing of ears
Am J Orthod Dentofacial Orthop
Hypersensitivity to pancreatic extracts in parents of patients with cystic fibrosis
J Allergy Clin Immunol
Food allergy—lessons From Asia
World Allergy Org J
Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
Lancet
Diagnosing peanut allergy with skin prick and specific IgE testing
J Allergy Clin Immunol
Update on food allergy
J Allergy Clin Immunol
The effects of roasting on the allergenic properties of peanut proteins
J Allergy Clin Immunol
Identification of sesame seed allergens by 2-dimensional proteomics and Edman sequencing: seed storage proteins as common food allergens
J Allergy Clin Immunol
The major allergen of sesame seeds (Sesamum indicum) is a 2S albumin
J Chromatogr B Biomed Sci Appl
Resolution of peanut allergy: case-control study
BMJ
Epidemiology of life-threatening and lethal anaphylaxis: a review
Allergy
Fatal and near-fatal anaphylactic reactions to food in children and adolescents
N Engl J Med
Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT). Adverse reactions to food and food ingredients
London (United Kingdom): Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment
Cited by (0)
Supported by a research grant from the National Peanut Board, United States. This grant supported the project costs, including the salary of G.D.T. over the study duration. G.L.'s salary was in part supported by the Aimwell Foundation. Support was also provided by the Department of Health via the National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London.
Disclosure of potential conflict of interest: G. Du Toit has received research support from the Immune Tolerance Network and the National Peanut Board, United States. Y. Katz has received research support from the Israel Dairy Board and has provided legal consultation or expert witness testimony on the subject of milk exposure. S. J. Maleki has received research support from the Georgia Peanut Commission. V. Turcanu has received research support from the Food Standards Agency (UK), the National Peanut Board, United States, the Immune Tolerance Network, and the Food Allergy and Anaphylaxis Network. G. Lack has consulted for the advisory boards of Synovate, Novartis-Xolair, and ALK-Abelló; has given lectures supported by SHS Nutricia, SHS International, and Nestlé; has received research support from the Immune Tolerance Network, the National Peanut Board, United States, the Food Standard Agency, the Food Allergy Initiative, the Food Allergy and Anaphylaxis Network, and the Medical Research Council; and has served as a scientific advisor for the Anaphylaxis Campaign and the National Peanut Board, United States. The rest of the authors have declared that they have no conflict of interest.